Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 5/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.31 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20376466 | 1.00 | FEN1 (0.36) | FEN1ALOX5APFFAR1HCRTR1HCRTR2 | |
| SCHEMBL20204881 | 0.92 | ALOX5AP (0.35) | FEN1ALOX5APFFAR1HTR2AHTR2C | |
| SCHEMBL20201608 | 0.86 | CXCR2 (0.34) | — | |
| SCHEMBL20201600 | 0.83 | FABP4 (0.36) | FEN1ALOX5APHCRTR1HCRTR2HTR2C | |
| SCHEMBL21533978 | 0.83 | FEN1 (0.37) | FEN1ALOX5APFFAR1 | |
| SCHEMBL21325048 | 0.83 | ALOX5AP (0.34) | FEN1ALOX5APFFAR1HCRTR1HCRTR2 | |
| SCHEMBL21325344 | 0.83 | ALOX5AP (0.34) | FEN1ALOX5APFFAR1HCRTR1HCRTR2 | |
| SCHEMBL21325054 | 0.79 | ALOX5AP (0.34) | FEN1ALOX5APFFAR1PARP10HTR2A | |
| SCHEMBL20190174 | 0.77 | S1PR1 (0.39) | FEN1ALOX5APHTR2AHTR2CHTR2B | |
| SCHEMBL20201618 | 0.77 | ALOX5AP (0.36) | FEN1ALOX5APFFAR1HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098207-A1 | HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018098204-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |