Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 7/20 | 0.41 |
| ▸ | HTR2B | P41595 | 6/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | HRH2 | P25021 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20188096 | 0.88 | HTR2C (0.42) | HTR2CHTR2BHTR2AADRB2HTR1A | |
| SCHEMBL18374457 | 0.88 | HTR2C (0.42) | HTR2CHTR2BHTR2AADRB2HTR1A | |
| Hydrochloric Acid SCHEMBL20338511 | 0.86 | HTR2C (0.43) | HTR2CHTR2BHTR2AADRB2HTR1A | |
| Hydrochloric Acid SCHEMBL20338513 | 0.86 | HTR2C (0.43) | HTR2CHTR2BHTR2AADRB2HTR1A | |
| SCHEMBL20206845 | 0.85 | HTR2C (0.38) | ACHEHTR2CHTR2BHTR2AADRB2 | |
| SCHEMBL6232386 | 0.82 | ACHE (0.58) | ACHELMNAALDH1A1BCHEL3MBTL1 | |
| SCHEMBL10152999 | 0.81 | KDM4E (0.54) | ACHEGAALMNACYP2D6MAPT | |
| SCHEMBL10206356 | 0.80 | HTT (0.46) | ACHETSHRLMNAMAPTALDH1A1 | |
| SCHEMBL26521879 | 0.79 | ACHE (0.39) | ACHEHTR2CCASRHTR2AADRB2 | |
| SCHEMBL140613 | 0.78 | HTR2C (0.43) | HTR2CHTR2BHTR2AADRB2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018128720-A1 | URACIL CONTAINING COMPOUNDS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-07-12 | — | — | WO | disclosed |
| WO-2018098208-A1 | NITROGEN RING LINKED DEOXYURIDINE TRIPHOSPHATASE INHIBITORS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018098204-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |