Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 12/20 | 0.42 |
| ▸ | HTR2B | P41595 | 8/20 | 0.42 |
| ▸ | HTR2A | P28223 | 7/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18374457 | 1.00 | HTR2C (0.42) | HTR2CHTR2BHTR2AADRB2HTR1A | |
| Hydrochloric Acid SCHEMBL20338513 | 0.98 | HTR2C (0.43) | HTR2CHTR2BHTR2AADRB2HTR1A | |
| Hydrochloric Acid SCHEMBL20338511 | 0.98 | HTR2C (0.43) | HTR2CHTR2BHTR2AADRB2HTR1A | |
| SCHEMBL20206848 | 0.88 | ACHE (0.41) | HTR2CHTR2BHTR2AADRB2HTR1A | |
| SCHEMBL20206845 | 0.82 | HTR2C (0.38) | HTR2CHTR2BHTR2AADRB2HTR1A | |
| SCHEMBL31447482 | 0.81 | HTT (0.44) | ADRB2TSHRLMNAMAPTALDH1A1 | |
| SCHEMBL28408399 | 0.81 | HTT (0.44) | ADRB2TSHRLMNAMAPTALDH1A1 | |
| SCHEMBL20201941 | 0.80 | ALDH1A1 (0.44) | ADRB2GAAALDH1A1 | |
| SCHEMBL18374263 | 0.78 | MAPT (0.39) | HTR2CHTR2BHTR2AADRB2GAA | |
| SCHEMBL12094250 | 0.78 | DUT (0.41) | HTR2CHTR2BHTR2AADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018128720-A1 | URACIL CONTAINING COMPOUNDS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-07-12 | — | — | WO | disclosed |
| WO-2018098207-A1 | HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |