Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 8/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20347946 | 0.85 | DUT (0.46) | DUTRIPK1IDO1TDO2GRM2 | |
| SCHEMBL21325419 | 0.83 | DUT (0.58) | DUTSCN9A | |
| SCHEMBL1409593 | 0.83 | DUT (0.45) | DUTRIPK1IDO1TDO2GRM2 | |
| SCHEMBL21325251 | 0.83 | DUT (0.45) | DUTRIPK1IDO1TDO2GRM2 | |
| SCHEMBL22414494 | 0.82 | DUT (0.45) | DUTRIPK1IDO1TDO2GRM2 | |
| SCHEMBL2304488 | 0.81 | SCN8A (0.43) | DUTRIPK1IDO1GRM2HTR2A | |
| SCHEMBL20188354 | 0.80 | DUT (0.43) | DUTRIPK1IDO1TDO2GRM2 | |
| SCHEMBL20347951 | 0.80 | DUT (0.42) | DUTRIPK1GRM2SCN9A | |
| SCHEMBL20202148 | 0.80 | GRM2 (0.43) | DUTRIPK1GRM2HTR2AHTR2C | |
| SCHEMBL16891348 | 0.80 | DUT (0.46) | DUTRIPK1IDO1TDO2GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098204-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |