Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 3/20 | 0.34 |
| ▸ | ACACA | Q13085 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18374073 | 0.78 | RIPK1 (0.42) | RIPK1MCHR1HTR2CIRAK4PDE4A | |
| Hydrochloric Acid SCHEMBL20188156 | 0.77 | RIPK1 (0.41) | RIPK1MCHR1HTR2CPDE4APDE4B | |
| Hydrochloric Acid SCHEMBL20188155 | 0.77 | RIPK1 (0.41) | RIPK1MCHR1HTR2CPDE4APDE4B | |
| SCHEMBL20376081 | 0.76 | RIPK1 (0.40) | RIPK1MCHR1HTR2CNFKB1NFKB2 | |
| SCHEMBL20207066 | 0.76 | RIPK1 (0.40) | RIPK1NFKB1NFKB2RELAPDE4A | |
| SCHEMBL20376082 | 0.73 | MRGPRX1 (0.38) | RIPK1NFKB1NFKB2RELAPDE4A | |
| SCHEMBL22479875 | 0.70 | RIPK1 (0.53) | RIPK1HTR2C | |
| SCHEMBL21325323 | 0.69 | RIPK1 (0.44) | RIPK1MCHR1HTR2CPDE4APDE4B | |
| SCHEMBL4516687 | 0.68 | MAOB (0.55) | RIPK1NFKB1NFKB2RELAPDE4A | |
| SCHEMBL13936012 | 0.68 | NFKB1 (0.45) | RIPK1ACACBACACANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098204-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |