Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20376082 | 0.88 | MRGPRX1 (0.38) | RIPK1MRGPRX1NFKB1NFKB2RELA | |
| SCHEMBL20376081 | 0.86 | RIPK1 (0.40) | RIPK1MRGPRX1NFKB1NFKB2RELA | |
| SCHEMBL20207588 | 0.81 | RIPK1 (0.43) | RIPK1MRGPRX1LMNASMN1; SMN2KDM4E | |
| SCHEMBL18374066 | 0.80 | RIPK1 (0.42) | RIPK1MRGPRX1LMNASMN1; SMN2KDM4E | |
| SCHEMBL4516687 | 0.78 | MAOB (0.55) | RIPK1NFKB1NFKB2RELAPDE4A | |
| SCHEMBL13936012 | 0.78 | NFKB1 (0.45) | RIPK1MRGPRX1NFKB1NFKB2RELA | |
| SCHEMBL7405753 | 0.78 | PDE4B (0.47) | RIPK1NFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL20207064 | 0.76 | RIPK1 (0.39) | RIPK1NFKB1NFKB2RELAPDE4A | |
| SCHEMBL5033170 | 0.75 | PDE4D (0.47) | CNR2FAAHCNR1PDE4APDE4B | |
| SCHEMBL4946009 | 0.74 | MAOB (0.50) | SMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098204-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |