Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.54 |
| ▸ | RELA | Q04206 | 3/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | SLC28A3 | Q9HAS3 | 2/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5088675 | 0.93 | NFKB1 (0.60) | MAOBNFKB1NFKB2RELATHRB | |
| SCHEMBL7405753 | 0.85 | PDE4B (0.47) | NFKB1NFKB2RELARIPK1CA12 | |
| SCHEMBL13936012 | 0.85 | NFKB1 (0.45) | MAOBNFKB1NFKB2RELARIPK1 | |
| SCHEMBL30167558 | 0.82 | ALDH1A1 (0.53) | MAOBNFKB1NFKB2RELATHRB | |
| SCHEMBL10809170 | 0.82 | ALDH1A1 (0.53) | MAOBNFKB1NFKB2RELATHRB | |
| SCHEMBL12009587 | 0.80 | MAOB (0.63) | MAOBNFKB1NFKB2RELATHRB | |
| SCHEMBL4946009 | 0.80 | MAOB (0.50) | MAOBCA9 | |
| SCHEMBL1448829 | 0.79 | MAOB (0.61) | MAOBTHRBSLC28A3CA12CA1 | |
| SCHEMBL29788611 | 0.79 | MAOB (0.61) | MAOBTHRBSLC28A3CA12CA1 | |
| SCHEMBL20207066 | 0.78 | RIPK1 (0.40) | NFKB1NFKB2RELARIPK1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054424-A1 | Optically active pyridine derivative and a medicament containing the same | MURATA TOSHIKI | 2009-02-26 | — | — | US | disclosed |
| US-20090054424-A1 | Optically active pyridine derivative and a medicament containing the same | MURATA TOSHIKI | 2009-02-26 | — | — | US | disclosed |
| US-20090054424-A1 | Optically active pyridine derivative and a medicament containing the same | MURATA TOSHIKI | 2009-02-26 | — | — | US | disclosed |
| US-7435743-B2 | Pyridine derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2008-10-14 | — | — | US | disclosed |
| US-7435743-B2 | Pyridine derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2008-10-14 | — | — | US | disclosed |
| US-7435743-B2 | Pyridine derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2008-10-14 | — | — | US | disclosed |
| US-7410986-B2 | 4-6-diphenyl pyridine derivatives as antiinflammatory agents | BAYER AKTIENGESELLSCHAFT (DE) | 2008-08-12 | — | — | US | disclosed |
| US-7375103-B2 | Optically active pyridine derivative and a medicament containing the same | BAYER HEALTHCARE AG (DE) | 2008-05-20 | — | — | US | disclosed |
| US-7375103-B2 | Optically active pyridine derivative and a medicament containing the same | BAYER HEALTHCARE AG (DE) | 2008-05-20 | — | — | US | disclosed |
| US-7375103-B2 | Optically active pyridine derivative and a medicament containing the same | BAYER HEALTHCARE AG (DE) | 2008-05-20 | — | — | US | disclosed |
| US-6984649-B1 | Pyridine derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2006-01-10 | — | — | US | disclosed |
| US-20050215547-A1 | Optically active pyridine derivative and a medicament containing the same | BAYER HEALTHCARE AG (DE) | 2005-09-29 | — | — | US | disclosed |
| EP-1487842-A1 | AN OPTICALLY ACITVE PYRIDINE DERIVATIVE AND A MEDICAMENT CONTAINING THE SAME | Bayer HealthCare AG (DE) | 2004-12-22 | — | — | EP | disclosed |
| US-20040097563-A1 | 4-6-Diphenyl pyridine derivatives as antiinflammatory agents | BAYER AKTIENGESELLSCHAFT (DE) | 2004-05-20 | — | — | US | disclosed |
| WO-2003076447-A1 | AN OPTICALLY ACITVE PYRIDINE DERIVATIVE AND A MEDICAMENT CONTAINING THE SAME | BAYER HEALTHCARE AG (DE) | 2003-09-18 | — | — | WO | disclosed |
| EP-1326856-A1 | PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK-BETA) INHIBITING ACTIVITY | Bayer Aktiengesellschaft (DE) | 2003-07-16 | — | — | EP | disclosed |
| US-6562811-B1 | Inhibit I kappa B kinase beta (IKK- beta or IKK-beta) activity, thus inhibit nuclear factor kappa B (NF- kappa B) and can be used for the prophylaxis and treatment of inflammation | BAYER AKTIENGESELLSCHAFT (DE) | 2003-05-13 | — | — | US | disclosed |
| WO-2002024651-A1 | A PROCESS FOR PRODUCING 2-AMINO-4,6-DISUBSTITUTED NICOTINIC ACID ESTER ANALOGS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-03-28 | — | — | WO | disclosed |
| WO-2002024679-A1 | PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK-β) INHIBITING ACTIVITY | BAYER AKTIENGESELLSCHAFT (DE) | 2002-03-28 | — | — | WO | disclosed |
| WO-2002024693-A1 | A PROCESS FOR PRODUCING 3,4-DIHYDRO NAPHTHYRIDINONE ANALOGS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097563-A1 | 4-6-Diphenyl pyridine derivatives as antiinflammatory agents | IL6, HRH4, CXCR6 | MAOB 2657/4885NFKB1 119/4885NFKB2 171/4885 |
| US-20090054424-A1 | Optically active pyridine derivative and a medicament containing the same | IL1B, NFKBIA, IL17A | MAOB 2162/4885NFKB1 19/4885NFKB2 24/4885 |
| US-20050215547-A1 | Optically active pyridine derivative and a medicament containing the same | IL1B, NFKBIA, IL1A | MAOB 2281/4885NFKB1 14/4885NFKB2 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.