Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | G6PD | P11413 | 1/20 | 0.69 |
| ▸ | CASP7 | P55210 | 1/20 | 0.69 |
| ▸ | CASP6 | P55212 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27804393 | 0.98 | G6PD (0.67) | G6PDCASP7CASP6KDM4EALDH1A1 | |
| SCHEMBL40536 | 0.85 | ALDH1A1 (0.54) | G6PDCASP7CASP6KDM4EALDH1A1 | |
| SCHEMBL717462 | 0.84 | G6PD (0.72) | G6PDCASP7CASP6KDM4EALDH1A1 | |
| SCHEMBL21114369 | 0.82 | CASP7 (1.00) | G6PDCASP7CASP6KDM4EALDH1A1 | |
| SCHEMBL30477210 | 0.82 | CASP7 (1.00) | G6PDCASP7CASP6KDM4EALDH1A1 | |
| SCHEMBL29430959 | 0.82 | CASP7 (1.00) | G6PDCASP7CASP6KDM4EALDH1A1 | |
| SCHEMBL88229 | 0.82 | CASP7 (1.00) | G6PDCASP7CASP6KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8584593 | 0.80 | CASP7 (0.96) | G6PDCASP7CASP6KDM4EALDH1A1 | |
| SCHEMBL120305 | 0.80 | G6PD (0.67) | G6PDCASP7CASP6KDM4EALDH1A1 | |
| Bromide SCHEMBL1026209 | 0.80 | CASP7 (0.96) | G6PDCASP7CASP6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8519168-B2 | Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds | MERCK SHARP & DOHME CORP. (US) | 2013-08-27 | — | — | US | claimed |
| US-20110160469-A1 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | MERCK SHARP & DOHME LLC | 2011-06-30 | — | — | US | claimed |
| CN-101932553-A | Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds | SCHERING CORP | 2010-12-29 | — | — | CN | claimed |
| EP-2178826-A1 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | SCHERING CORPORATION (US) | 2010-04-28 | — | — | EP | claimed |
| WO-2009005801-A1 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | SCHERING CORPORATION (US) | 2009-01-08 | — | — | WO | claimed |
| WO-2024127363-A1 | TYK2 PSEUDOKINASE LIGANDS AND USES THEREOF | ALEMBIC PHARMACEUTICALS LIMITED (IN) | 2024-06-20 | — | — | WO | disclosed |
| US-8519168-B2 | Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds | MERCK SHARP & DOHME CORP. (US) | 2013-08-27 | — | — | US | disclosed |
| CN-101181188-B | Method for staining cutin fiber and staining reagent box or device | OREAL | 2013-04-03 | — | — | CN | disclosed |
| CN-101919833-B | Application of aromatic compounds in preparing Caspase 3 inhibitor | UNIV JINAN | 2012-01-11 | — | — | CN | disclosed |
| US-20110160469-A1 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | MERCK SHARP & DOHME LLC | 2011-06-30 | — | — | US | disclosed |
| CN-101932553-A | Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds | SCHERING CORP | 2010-12-29 | — | — | CN | disclosed |
| CN-101919833-A | Application of aromatic compounds in preparing Caspase 3 inhibitor | UNIV JINAN | 2010-12-22 | — | — | CN | disclosed |
| WO-2009005801-A1 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | SCHERING CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |
| CN-101181188-A | Method for staining cutin fiber and staining reagent box or device | OREAL (FR) | 2008-05-21 | — | — | CN | disclosed |
| US-6429311-B2 | CHEMICAL INTERMEDIATE FOR HYPOTENSIVE AGENTS, BACTERICIDES, FUNGICIDES, ANTIPYRETICS AND ANTIDEPRESSANTS | SEPRACOR INC. | 2002-08-06 | — | — | US | disclosed |
| US-20010018518-A1 | Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof | GAO YUN (US) | 2001-08-30 | — | — | US | disclosed |
| US-6184377-B1 | ANTIPYRETIC, HYPOTENSIVE, ANTIBACTERIAL, ANTIFUNGAL OR CENTRAL NERVOUS SYSTEM (CNS) ACTIVITY, AS WELL AS THE ABILITY TO INHIBIT ENZYMES | SEPRACOR INC. | 2001-02-06 | — | — | US | disclosed |
| US-4517005-A | Aminophenol urease inhibitors and urease inhibited urea based fertilizer compositions | ALLIED CORPORATION (US) | 1985-05-14 | — | — | US | disclosed |
| US-4460600-A | Adjacently substituted ketal derivatives of cycloalkane-amide analgesics | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4359476-A | Adjacently substituted cycloalkane-amide analgesics | THE UPJOHN COMPANY (US) | 1982-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160469-A1 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | CCL2, CCR1, CXCR1 | G6PD 836/4885CASP7 2930/4885CASP6 3592/4885 |
| US-20010018518-A1 | Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof | NQO2, ASNS, AAAS | G6PD 2578/4885CASP7 2562/4885CASP6 3437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.