Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD1 | P11586 | 2/20 | 0.47 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.47 |
| ▸ | ERN1 | O75460 | 5/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 11/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | FHIT | P49789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21354138 | 0.88 | MTHFD1 (0.47) | MTHFD1MTHFD2ERN1PTGDR2DRD2 | |
| SCHEMBL24691517 | 0.87 | MTHFD1 (0.46) | MTHFD1MTHFD2ERN1PTGDR2DRD2 | |
| SCHEMBL20208622 | 0.84 | HSD17B10 (0.49) | MTHFD1MTHFD2ERN1FHIT | |
| SCHEMBL21354099 | 0.84 | ERN1 (0.58) | MTHFD1MTHFD2ERN1PTGDR2DRD2 | |
| SCHEMBL20208640 | 0.82 | ERN1 (0.49) | MTHFD1MTHFD2ERN1PTGDR2DRD2 | |
| SCHEMBL21417110 | 0.78 | TMEM97 (0.49) | MTHFD1MTHFD2ERN1 | |
| SCHEMBL20208684 | 0.74 | CXCR3 (0.47) | MTHFD1MTHFD2ERN1 | |
| SCHEMBL18928246 | 0.73 | PTGDR2 (0.45) | PTGDR2 | |
| SCHEMBL21354096 | 0.72 | MTHFD2 (0.48) | MTHFD1MTHFD2ERN1FHIT | |
| SCHEMBL21354142 | 0.72 | MTHFD2 (0.51) | MTHFD1MTHFD2ERN1FHIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3546463-B1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | DAIICHI SANKYO CO LTD (JP) | 2022-12-07 | — | — | EP | disclosed |
| EP-3546463-A1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | Daiichi Sankyo Co., Ltd. (JP) | 2019-10-02 | — | — | EP | disclosed |
| WO-2018097162-A1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | 第一三共株式会社 | 2018-05-31 | — | — | WO | disclosed |