Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 2/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | PTGFR | P43088 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | TPMT | P51580 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21416879 | 0.82 | PYGL (0.51) | PYGLAKR1C3AKR1C2PTGFRCA12 | |
| SCHEMBL20209032 | 0.80 | NEU3 (0.51) | PYGLAKR1C3AKR1C2PTGFRCA12 | |
| SCHEMBL24691709 | 0.79 | PYGL (0.47) | PYGLAKR1C3AKR1C2PTGFRCA12 | |
| SCHEMBL3547168 | 0.79 | EGLN1 (0.46) | PYGLAKR1C3AKR1C2CA12CA1 | |
| SCHEMBL20209304 | 0.78 | PGR (0.51) | PYGLAKR1C3AKR1C2PTGFRAURKA | |
| SCHEMBL3367612 | 0.77 | RXRA (0.54) | PYGLAKR1C3AKR1C2CA12CA1 | |
| SCHEMBL12886172 | 0.76 | NOTUM (0.57) | PYGLPTGFRCA12CA1CA2 | |
| SCHEMBL415787 | 0.76 | PYGL (0.54) | PYGLAKR1C3AKR1C2PTGFRAURKA | |
| SCHEMBL20209305 | 0.76 | PYGL (0.44) | PYGLAKR1C3AKR1C2PTGFRCA12 | |
| SCHEMBL14213194 | 0.76 | RXRA (0.49) | PYGLAKR1C3AKR1C2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3546463-A1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | Daiichi Sankyo Co., Ltd. (JP) | 2019-10-02 | — | — | EP | disclosed |
| WO-2018097162-A1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | 第一三共株式会社 | 2018-05-31 | — | — | WO | disclosed |