Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEU3 | Q9UQ49 | 1/20 | 0.51 |
| ▸ | PYGL | P06737 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | PTGFR | P43088 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.42 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 2/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20209304 | 0.86 | PGR (0.51) | PYGLAKR1C3AKR1C2PTGFRKDM4E | |
| SCHEMBL5364834 | 0.82 | SMN1; SMN2 (0.58) | NEU3PYGLSMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL20209033 | 0.80 | PYGL (0.49) | PYGLAKR1C3AKR1C2PTGFRKDM4E | |
| SCHEMBL16887440 | 0.80 | MRGPRX1 (0.47) | SMN1; SMN2KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL21416879 | 0.80 | PYGL (0.51) | PYGLAKR1C3AKR1C2PTGFRKDM4E | |
| SCHEMBL15220190 | 0.78 | IDH1 (0.47) | ALDH1A1CNR2ALPLKIF11 | |
| SCHEMBL12998566 | 0.78 | PTGS1 (0.61) | NEU3AKR1C3SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL29791247 | 0.77 | NEU3 (0.63) | NEU3SMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL567311 | 0.77 | NEU3 (0.63) | NEU3SMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL24691709 | 0.77 | PYGL (0.47) | PYGLAKR1C3AKR1C2PTGFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3546463-B1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | DAIICHI SANKYO CO LTD (JP) | 2022-12-07 | — | — | EP | disclosed |
| EP-3546463-B1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | DAIICHI SANKYO CO LTD (JP) | 2022-12-07 | — | — | EP | disclosed |
| US-10774087-B2 | Sulfonamide derivative having coumarin skeleton | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-09-15 | — | — | US | disclosed |
| US-10774087-B2 | Sulfonamide derivative having coumarin skeleton | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-09-15 | — | — | US | disclosed |
| EP-3546463-A1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | Daiichi Sankyo Co., Ltd. (JP) | 2019-10-02 | — | — | EP | disclosed |
| EP-3546463-A1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | Daiichi Sankyo Co., Ltd. (JP) | 2019-10-02 | — | — | EP | disclosed |
| US-20190284198-A1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-09-19 | — | — | US | disclosed |
| US-20190284198-A1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-09-19 | — | — | US | disclosed |
| WO-2018097162-A1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | 第一三共株式会社 | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190284198-A1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | MTHFD1, MTHFD2, DHFR | NEU3 4243/4885PYGL 3034/4885AKR1C3 408/4885 |
| US-10774087-B2 | Sulfonamide derivative having coumarin skeleton | MTHFD1, MTHFD2, DHFR | NEU3 4243/4885PYGL 3034/4885AKR1C3 408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.