Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24062105 | 0.88 | NAMPT (0.44) | GRM5NAMPTHPGDKDM4E | |
| SCHEMBL20214414 | 0.86 | SMN1; SMN2 (0.57) | GRM5ALDH1A1CYP1A2CYP3A4NAMPT | |
| SCHEMBL22915971 | 0.86 | SLC6A7 (0.52) | ALDH1A1NAMPTHPGDKDM4EMGLL | |
| SCHEMBL22915969 | 0.86 | HPGD (0.51) | GRM5CYP3A4NAMPTHPGDKDM4E | |
| SCHEMBL24062095 | 0.85 | NAMPT (0.47) | GRM5ALDH1A1NAMPTHPGDKDM4E | |
| SCHEMBL22915890 | 0.85 | KDM4E (0.47) | GRM5NAMPTHPGDKDM4E | |
| SCHEMBL24062103 | 0.84 | HPGD (0.51) | PKMNAMPTHPGDKDM4E | |
| SCHEMBL22916012 | 0.83 | ALDH1A1 (0.53) | GRM5ALDH1A1HPGDL3MBTL1CA12 | |
| SCHEMBL22915942 | 0.82 | GRM5 (0.50) | GRM5ALDH1A1CYP1A2CYP3A4NAMPT | |
| Oxalic Acid SCHEMBL6423881 | 0.82 | NAMPT (0.44) | GRM5ALDH1A1NAMPTHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11186572-B2 | Bacterial glutaminyl cyclases and inhibitors thereof for use in the treatment of periodontitis | FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) | 2021-11-30 | — | — | US | disclosed |
| EP-3548613-A1 | BACTERIAL GLUTAMINYL CYCLASES AND INHIBITORS THEREOF FOR USE IN THE TREATMENT OF PERIODONTITIS | Fraunhofer Gesellschaft zur Förderung der Angewand (DE) | 2019-10-09 | — | — | EP | disclosed |
| WO-2018100159-A1 | BACTERIAL GLUTAMINYL CYCLASES AND INHIBITORS THEREOF FOR USE IN THE TREATMENT OF PERIODONTITIS | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2018-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11186572-B2 | Bacterial glutaminyl cyclases and inhibitors thereof for use in the treatment of periodontitis | GMPS, QPCT, GLS | GRM5 540/4885PKM 2708/4885ALDH1A1 2706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.