Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7930788 | 0.82 | ALDH1A1 (0.64) | ALDH1A1GAAHSD17B10KDM4EKMT2A | |
| SCHEMBL947416 | 0.80 | GAA (0.58) | ALDH1A1GAALMNAMCL1HSD17B10 | |
| SCHEMBL7018956 | 0.80 | APP (0.56) | GAAKMT2AL3MBTL1APPMEN1 | |
| SCHEMBL194451 | 0.79 | ALDH1A1 (0.46) | ALDH1A1GAALMNAHSD17B10KDM4E | |
| Hydrochloric Acid SCHEMBL9893410 | 0.78 | APP (0.55) | ALDH1A1GAAKMT2AL3MBTL1APP | |
| SCHEMBL1838872 | 0.76 | ALDH1A1 (0.69) | ALDH1A1GAAHSD17B10KDM4EKMT2A | |
| SCHEMBL5404445 | 0.75 | ALDH1A1 (0.55) | ALDH1A1GAALMNAHSD17B10KDM4E | |
| SCHEMBL20509838 | 0.75 | ALDH1A1 (0.55) | ALDH1A1GAAHSD17B10KDM4EKMT2A | |
| SCHEMBL31655455 | 0.75 | ALDH1A1 (0.55) | ALDH1A1GAAHSD17B10KDM4EKMT2A | |
| SCHEMBL11354404 | 0.75 | ALDH1A1 (0.55) | ALDH1A1GAAHSD17B10KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220089549-A1 | INHIBITORS OF PROTEIN ARGININE DEIMINASES (PADS) AND METHODS OF PREPARATION AND USE THEREOF | UNIV MASSACHUSETTS (US) | 2022-03-24 | — | — | US | disclosed |
| US-11208386-B2 | Inhibitors of protein arginine deiminases (PADs) and methods of preparation and use thereof | UNIVERSITY OF MASSACHUSETTS (US) | 2021-12-28 | — | — | US | disclosed |
| US-11208386-B2 | Inhibitors of protein arginine deiminases (PADs) and methods of preparation and use thereof | UNIVERSITY OF MASSACHUSETTS (US) | 2021-12-28 | — | — | US | disclosed |
| US-20200339518-A1 | INHIBITORS OF PROTEIN ARGININE DEIMINASES (PADS) AND METHODS OF PREPARATION AND USE THEREOF | UNIV MASSACHUSETTS (US) | 2020-10-29 | — | — | US | disclosed |
| US-20200339518-A1 | INHIBITORS OF PROTEIN ARGININE DEIMINASES (PADS) AND METHODS OF PREPARATION AND USE THEREOF | UNIV MASSACHUSETTS (US) | 2020-10-29 | — | — | US | disclosed |
| WO-2018102262-A1 | INHIBITORS OF PROTEIN ARGININE DEIMINASES (PADS) AND METHODS OF PREPARATION AND USE THEREOF | UNIVERSITY OF MASSACHUSETTS (US) | 2018-06-07 | — | — | WO | disclosed |
| WO-2018102262-A1 | INHIBITORS OF PROTEIN ARGININE DEIMINASES (PADS) AND METHODS OF PREPARATION AND USE THEREOF | UNIVERSITY OF MASSACHUSETTS (US) | 2018-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11208386-B2 | Inhibitors of protein arginine deiminases (PADs) and methods of preparation and use thereof | PADI2, PADI1, PADI4 | ALDH1A1 813/4885GAA 2089/4885LMNA 3360/4885 |
| US-20220089549-A1 | INHIBITORS OF PROTEIN ARGININE DEIMINASES (PADS) AND METHODS OF PREPARATION AND USE THEREOF | PADI2, PADI1, PADI4 | ALDH1A1 813/4885GAA 2089/4885LMNA 3360/4885 |
| US-20200339518-A1 | INHIBITORS OF PROTEIN ARGININE DEIMINASES (PADS) AND METHODS OF PREPARATION AND USE THEREOF | PADI2, PADI1, PADI4 | ALDH1A1 813/4885GAA 2089/4885LMNA 3360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.