Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.49 |
| ▸ | KDR | P35968 | 11/20 | 0.49 |
| ▸ | IGF1R | P08069 | 10/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371607 | 0.89 | MET (0.57) | METKDRAXL | |
| SCHEMBL371815 | 0.85 | MET (0.56) | METKDRAXL | |
| SCHEMBL20525560 | 0.83 | LMNA (0.44) | METAXL | |
| SCHEMBL20525637 | 0.80 | LMNA (0.44) | METAXL | |
| SCHEMBL15426783 | 0.79 | MET (0.47) | METKDRIGF1RAXL | |
| SCHEMBL29741382 | 0.77 | LMNA (0.61) | — | |
| SCHEMBL4899009 | 0.76 | MET (0.48) | MET | |
| SCHEMBL2357525 | 0.76 | MET (0.52) | METKDRIGF1R | |
| SCHEMBL199658 | 0.76 | TRPA1 (0.53) | METKDRIGF1RAXLTRPA1 | |
| SCHEMBL29812085 | 0.76 | TRPA1 (0.53) | METKDRIGF1RAXLTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2018-06-06 | — | — | EP | disclosed |