Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1E | P28566 | 3/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.45 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.43 |
| ▸ | ITK | Q08881 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14863447 | 0.88 | FFAR2 (0.45) | HTR1ES1PR3FFAR2MEN1LMNA | |
| SCHEMBL14863461 | 0.84 | FFAR2 (0.48) | FFAR2PDPK1ITKCYP3A4TTK | |
| SCHEMBL14863451 | 0.84 | FFAR2 (0.48) | FFAR2PDPK1ITKCYP3A4TTK | |
| SCHEMBL14863553 | 0.84 | FFAR2 (0.48) | FFAR2PDPK1ITKCYP3A4TTK | |
| SCHEMBL15477042 | 0.81 | CYP3A4 (0.55) | CYP3A4TTKAURKBINCENP | |
| SCHEMBL15476924 | 0.78 | TTK (0.67) | PDPK1ITKCYP3A4TTKAURKB | |
| SCHEMBL20217169 | 0.75 | HTR1E (0.40) | HTR1ES1PR3FFAR2MEN1LMNA | |
| SCHEMBL20217418 | 0.74 | FFAR2 (0.45) | HTR1ES1PR3FFAR2MEN1LMNA | |
| SCHEMBL14863558 | 0.72 | ULK1 (0.45) | HTR1ES1PR3MEN1LMNAKMT2A | |
| SCHEMBL14863487 | 0.72 | HTR1E (0.43) | HTR1ES1PR3MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |