Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 1/20 | 0.45 |
| ▸ | HTR1E | P28566 | 3/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.40 |
| ▸ | NPY2R | P49146 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217431 | 0.80 | KDR (0.41) | HTR1ES1PR3MEN1LMNAKMT2A | |
| SCHEMBL20217220 | 0.80 | HTR1E (0.55) | HTR1ES1PR3MEN1LMNAKMT2A | |
| SCHEMBL20217145 | 0.77 | CYP3A4 (0.47) | S1PR3MEN1KMT2AALDH1A1 | |
| SCHEMBL20217368 | 0.76 | CYP3A4 (0.46) | S1PR3MEN1KMT2AALDH1A1 | |
| SCHEMBL20217424 | 0.74 | HTR1E (0.45) | FFAR2HTR1ES1PR3MEN1LMNA | |
| SCHEMBL14863447 | 0.72 | FFAR2 (0.45) | FFAR2HTR1ES1PR3MEN1LMNA | |
| SCHEMBL14873325 | 0.72 | FFAR2 (0.47) | FFAR2HTR1ES1PR3MEN1LMNA | |
| SCHEMBL20217169 | 0.69 | HTR1E (0.40) | FFAR2HTR1ES1PR3MEN1LMNA | |
| SCHEMBL20217332 | 0.69 | TRPM8 (0.43) | MEN1KMT2ALRRK2ALDH1A1 | |
| SCHEMBL20217633 | 0.69 | TRPM8 (0.43) | MEN1KMT2ALRRK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |