Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 4/20 | 0.40 |
| ▸ | MMP2 | P08253 | 3/20 | 0.40 |
| ▸ | MMP14 | P50281 | 3/20 | 0.40 |
| ▸ | MMP3 | P08254 | 3/20 | 0.40 |
| ▸ | MMP7 | P09237 | 3/20 | 0.40 |
| ▸ | MMP13 | P45452 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3423682 | 0.81 | PREP (0.44) | HDAC6NAMPTSLC6A1SLC6A11 | |
| SCHEMBL3423687 | 0.71 | PREP (0.44) | NAMPTPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL3423684 | 0.70 | PREP (0.46) | NAMPTPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL10177655 | 0.69 | MMP2 (0.40) | MMP9MMP2MMP14MMP3MMP7 | |
| SCHEMBL14978137 | 0.69 | MMP2 (0.40) | MMP9MMP2MMP14MMP3MMP7 | |
| SCHEMBL9908643 | 0.69 | MMP2 (0.40) | MMP9MMP2MMP14MMP3MMP7 | |
| SCHEMBL3904345 | 0.69 | SLC6A11 (0.44) | SLC6A1SLC6A11SMN1; SMN2 | |
| SCHEMBL31534289 | 0.68 | HDAC1 (0.38) | HDAC6NAMPTHDAC1SLC6A1SLC6A11 | |
| SCHEMBL10177664 | 0.68 | HDAC6 (0.40) | HDAC6NAMPTHDAC1SLC6A1SLC6A11 | |
| SCHEMBL16393116 | 0.68 | HDAC1 (0.38) | HDAC6NAMPTHDAC1SLC6A1SLC6A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329924-A1 | SIRNA THERAPY FOR TRANSTHYRETIN (TTR) RELATED OCULAR AMYLOIDOSIS | Alnylam Pharmaceuticals, Inc. (US) | 2018-06-06 | — | — | EP | disclosed |