SCHEMBL202186

SCHEMBL202186

NC(=O)c1c(Cl)ccc(O)c1F

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HSD17B1 P14061 6/20 0.46
HSD17B2 P37059 6/20 0.46
DPP4 P27487 1/20 0.41
PBRM1 Q86U86 1/20 0.39
CXCR2 P25025 2/20 0.38
CXCR1 P25024 1/20 0.38
WEE1 P30291 1/20 0.37
PKMYT1 Q99640 1/20 0.37
CYP3A4 P08684 1/20 0.37
MAPK1 P28482 1/20 0.37
KMT2A Q03164 1/20 0.36
ATM Q13315 1/20 0.36
MAP2 P11137 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1495295 0.82 DPP4 (0.57) HSD17B1HSD17B2DPP4CYP3A4MAPK1
SCHEMBL5173385 0.79 CYP3A4 (0.50) DPP4PBRM1CXCR2CXCR1WEE1
SCHEMBL201485 0.79 HSD17B1 (0.44) HSD17B1HSD17B2CYP3A4
SCHEMBL1224060 0.78 CXCR2 (0.43) DPP4PBRM1CXCR2CXCR1MAPK1
SCHEMBL3823076 0.78 POLB (0.42) DPP4PBRM1KMT2AATM
SCHEMBL206143 0.78 DPP4 (0.42) DPP4PBRM1CXCR2CXCR1WEE1
SCHEMBL1495245 0.76 CA12 (0.50) HSD17B1HSD17B2CYP3A4KMT2A
SCHEMBL6818860 0.75 PBRM1 (0.41) PBRM1KMT2AATMMAP2
SCHEMBL202047 0.74 KDM4E (0.46) CYP3A4KMT2A
SCHEMBL8587726 0.74 DPP4 (0.64) DPP4PBRM1CXCR2CXCR1WEE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250206755-A1 ANTIMICROBIAL AGENTS RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2025-06-26 US disclosed
US-20250179008-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. (US) 2025-06-05 US disclosed
US-11129814-B2 Antimicrobial agents TAXIS PHARMACEUTICALS, INC. (US) 2021-09-28 US disclosed
EP-2917212-B1 ANTIMICROBIAL AGENTS UNIV RUTGERS (US) 2019-06-12 EP disclosed
US-20180338957-A1 ANTIMICROBIAL AGENTS RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2018-11-29 US disclosed
US-10071082-B2 Antimicrobial agents RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2018-09-11 US disclosed
US-20180179225-A1 ANTIMICROBIAL AGENTS RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2018-06-28 US disclosed
US-20160367531-A1 ANTIMICROBIAL AGENTS RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2016-12-22 US disclosed
US-9475783-B2 Antimicrobial agents RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2016-10-25 US disclosed
US-9458150-B2 Antimicrobial agents RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2016-10-04 US disclosed
CN-101404989-B Antibacterial agent PROLYSIS LTD 2011-10-05 CN disclosed
EP-1996180-B1 BENZAMIDE AND PYRIDYLAMIDE DERIVATIVES AS ANTIBACTERIAL AGENTS BIOTA EUROPE LTD (GB) 2011-08-03 EP disclosed
EP-1996180-B1 BENZAMIDE AND PYRIDYLAMIDE DERIVATIVES AS ANTIBACTERIAL AGENTS BIOTA EUROPE LTD (GB) 2011-08-03 EP disclosed
CN-102008459-A Antibacterial agents PROLYSIS LTD 2011-04-13 CN disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
CN-101404989-A Antibacterial agent PROLYSIS LTD (GB) 2009-04-08 CN disclosed
WO-2008018639-A2 GLYCINE TRANSPORTER INHIBITOR TAISHO PHARMACEUTICAL CO., LTD. (JP) 2008-02-14 WO disclosed
WO-2007107758-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2007-09-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180338957-A1 ANTIMICROBIAL AGENTS MRPL21, SPOUT1, LSS HSD17B1 3956/4885HSD17B2 4095/4885DPP4 762/4885
US-11129814-B2 Antimicrobial agents MRPL21, SPOUT1, LSS HSD17B1 3956/4885HSD17B2 4095/4885DPP4 762/4885
US-20160367531-A1 ANTIMICROBIAL AGENTS CFTR, MRPL21, ARG1 HSD17B1 3123/4885HSD17B2 3540/4885DPP4 1074/4885
US-10071082-B2 Antimicrobial agents CFTR, MRPL21, ARG1 HSD17B1 3123/4885HSD17B2 3540/4885DPP4 1074/4885
US-20250206755-A1 ANTIMICROBIAL AGENTS CFTR, MRPL21, ARG1 HSD17B1 3123/4885HSD17B2 3540/4885DPP4 1074/4885
US-20250179008-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 HSD17B1 2303/4885HSD17B2 2276/4885DPP4 2954/4885
US-20100173933-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 HSD17B1 2303/4885HSD17B2 2276/4885DPP4 2954/4885
US-20180179225-A1 ANTIMICROBIAL AGENTS CFTR, MRPL21, ARG1 HSD17B1 3123/4885HSD17B2 3540/4885DPP4 1074/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.