SCHEMBL20219239

SCHEMBL20219239

Cc1ccc2c(c1)C(C[Si](C)(C)C)=CC2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 1/20 0.39
ADORA1 P30542 1/20 0.35
METAP1 P53582 3/20 0.34
ACHE P22303 2/20 0.34
PARP1 P09874 1/20 0.33
PARP10 Q53GL7 1/20 0.33
CYP19A1 P11511 4/20 0.33
CYP11B2 P19099 2/20 0.33
NQO2 P16083 2/20 0.32
MTNR1A P48039 2/20 0.32
MTNR1B P49286 2/20 0.32
KDM4E B2RXH2 2/20 0.31
MAPT P10636 2/20 0.31
ALDH1A1 P00352 1/20 0.30
POLB P06746 1/20 0.30
GAA P10253 1/20 0.30
PKM P14618 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
HTR2A P28223 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20219236 0.86 METAP1 (0.34) METAP1PARP10KDM4EMAPTALDH1A1
SCHEMBL17559540 0.77 HTR6 (0.49) HTR7
SCHEMBL11768880 0.76 HTR7 (0.49) HTR7ADORA1METAP1ACHEPARP1
SCHEMBL19052404 0.75 HTR7 (0.32) HTR7
SCHEMBL20780378 0.74 CDC25B (0.31) HTR7
SCHEMBL20219233 0.74 CDC25B (0.34) HTR7
SCHEMBL30933590 0.71 METAP1 (0.41) ADORA1METAP1ACHEPARP1PARP10
SCHEMBL9629516 0.71 METAP1 (0.41) ADORA1METAP1ACHEPARP1PARP10
SCHEMBL28115385 0.68 METAP1 (0.39) ADORA1METAP1ACHEPARP1PARP10
SCHEMBL28115384 0.68 METAP1 (0.39) ADORA1METAP1ACHEPARP1PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3330296-B1 METHOD FOR PREPARING SUPPORTED METALLOCENE CATALYST LG CHEMICAL LTD (KR) 2020-02-19 EP disclosed
WO-2019039839-A9 METHOD FOR EVALUATING INJECTION PHYSICAL PROPERTY OF PLASTIC RESIN, AND POLYETHYLENE RESIN SUITABLE FOR INJECTION MOLDING 주식회사 엘지화학 2019-07-25 WO disclosed
WO-2019039839-A2 METHOD FOR EVALUATING INJECTION PHYSICAL PROPERTY OF PLASTIC RESIN, AND POLYETHYLENE RESIN SUITABLE FOR INJECTION MOLDING 주식회사 엘지화학 2019-02-28 WO disclosed
EP-3330296-A1 METHOD FOR PREPARING SUPPORTED HYBRID METALLOCENE CATALYST, AND SUPPORTED HYBRID METALLOCENE CATALYST PREPARED USING SAME LG Chem, Ltd. (KR) 2018-06-06 EP disclosed