Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20219723 | 0.92 | ALDH1A1 (0.38) | TLR7TLR8MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL20219346 | 0.88 | ALDH1A1 (0.40) | KMT2AMEN1TSHRTLR7TLR8 | |
| SCHEMBL15470018 | 0.88 | TLR7 (0.49) | KMT2AL3MBTL1CYP1A2MEN1TSHR | |
| SCHEMBL20219600 | 0.84 | CNR1 (0.39) | TLR7TLR8MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL20219324 | 0.84 | CHRNB2 (0.47) | KMT2ACYP1A2CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL23472466 | 0.84 | CYP1A2 (0.45) | MAPK1KMT2ACYP1A2MEN1CYP3A4 | |
| SCHEMBL20219259 | 0.84 | ALDH1A1 (0.38) | CYP1A2CYP3A4TLR7TLR8ALDH1A1 | |
| SCHEMBL20219572 | 0.82 | CYP2D6 (0.43) | CYP1A2CYP2C19CYP3A4CYP2C9TSHR | |
| SCHEMBL20219715 | 0.81 | HDAC3 (0.46) | NPSR1TLR7MTNR1AMTNR1BMAPT | |
| SCHEMBL13195680 | 0.81 | FLT3 (0.41) | MAPK1KMT2ACYP1A2CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |