Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15470045 | 0.88 | TLR7 (0.45) | TLR8TLR7 | |
| SCHEMBL20219327 | 0.88 | MAPK1 (0.44) | ALDH1A1MAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL20219259 | 0.88 | ALDH1A1 (0.38) | ALDH1A1POLBGAKTLR8TLR7 | |
| SCHEMBL20219715 | 0.87 | HDAC3 (0.46) | TP53MAPTHTTTLR7HDAC3 | |
| SCHEMBL20219723 | 0.86 | ALDH1A1 (0.38) | ALDH1A1POLBTLR8TLR7MTNR1A | |
| SCHEMBL23472210 | 0.85 | MTNR1B (0.47) | MAPTTLR8TLR7MTNR1AMTNR1B | |
| SCHEMBL13195680 | 0.85 | FLT3 (0.41) | ALDH1A1POLBMAPTTSHRTLR8 | |
| SCHEMBL20219725 | 0.82 | MGLL (0.47) | MAPTLMNASMN1; SMN2TLR7HDAC3 | |
| SCHEMBL20219572 | 0.81 | CYP2D6 (0.43) | ALDH1A1MAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL20219401 | 0.81 | ALDH1A1 (0.43) | ALDH1A1POLBLMNATSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |