Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20219327 | 0.92 | MAPK1 (0.44) | ALDH1A1TLR7TLR8MTNR1AMTNR1B | |
| SCHEMBL20219259 | 0.90 | ALDH1A1 (0.38) | ALDH1A1POLBTLR7TLR8 | |
| SCHEMBL20219600 | 0.90 | CNR1 (0.39) | ALDH1A1POLBTLR7TLR8FLT3 | |
| SCHEMBL15470017 | 0.87 | TLR7 (0.47) | TLR7TLR8 | |
| SCHEMBL20219346 | 0.86 | ALDH1A1 (0.40) | ALDH1A1POLBTLR7TLR8MTNR1A | |
| SCHEMBL20219695 | 0.84 | ALDH1A1 (0.37) | ALDH1A1POLBTLR7TLR8AHR | |
| SCHEMBL20219601 | 0.84 | TLR7 (0.37) | ALDH1A1POLBTLR7TLR8FLT3 | |
| SCHEMBL23472288 | 0.83 | TLR8 (0.38) | TLR7TLR8CRHR1 | |
| SCHEMBL20219572 | 0.83 | CYP2D6 (0.43) | ALDH1A1TLR7TLR8 | |
| SCHEMBL23472526 | 0.82 | TLR8 (0.47) | ALDH1A1POLBTLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |