Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 12/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472392 | 0.94 | CDK1 (0.36) | TLR7TLR8CDK1CDK5BCHE | |
| SCHEMBL20219653 | 0.87 | TLR8 (0.43) | TLR7TLR8 | |
| SCHEMBL20219459 | 0.84 | TLR8 (0.33) | TLR7TLR8CRHR1BCHE | |
| SCHEMBL23472365 | 0.81 | TLR8 (0.45) | TLR7TLR8 | |
| SCHEMBL20219693 | 0.78 | TLR8 (0.35) | TLR7TLR8CDK1CDK5BCHE | |
| SCHEMBL15470301 | 0.71 | TLR7 (0.42) | TLR7TLR8 | |
| SCHEMBL20386630 | 0.71 | TLR7 (0.42) | TLR7TLR8 | |
| SCHEMBL23472650 | 0.71 | CRHR1 (0.34) | TLR7TLR8CRHR1 | |
| SCHEMBL20219365 | 0.69 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL23472531 | 0.69 | CRHR1 (0.34) | TLR7TLR8CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |