Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20219459 | 0.94 | TLR8 (0.33) | TLR8TLR7BCHENTRK1TP53 | |
| SCHEMBL20219365 | 0.92 | CRHR1 (0.34) | — | |
| SCHEMBL23472365 | 0.85 | TLR8 (0.45) | TLR8TLR7KCNH2 | |
| SCHEMBL23472392 | 0.84 | CDK1 (0.36) | TLR8TLR7BCHEKCNH2CDK1 | |
| SCHEMBL20219653 | 0.79 | TLR8 (0.43) | TLR8TLR7KCNH2 | |
| SCHEMBL20219416 | 0.78 | TLR7 (0.34) | TLR8TLR7BCHECDK1CDK5 | |
| SCHEMBL20386798 | 0.74 | TLR8 (0.40) | TLR8TLR7KCNH2CDK1CDK5 | |
| SCHEMBL23472261 | 0.74 | TLR8 (0.44) | TLR8TLR7KCNH2TP53CDK1 | |
| SCHEMBL20219542 | 0.72 | TLR8 (0.43) | TLR8TLR7KCNH2 | |
| SCHEMBL15470288 | 0.72 | TLR8 (0.43) | TLR8TLR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |