Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 11/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 10/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13195805 | 0.88 | TLR7 (0.57) | TLR8TLR7CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL23472323 | 0.85 | TLR8 (0.54) | TLR8TLR7CYP1A2CYP2D6CASP6 | |
| SCHEMBL23472526 | 0.82 | TLR8 (0.47) | TLR8TLR7CYP3A4ALDH1A1LMNA | |
| SCHEMBL23472288 | 0.80 | TLR8 (0.38) | TLR8TLR7CYP3A4LMNASMN1; SMN2 | |
| SCHEMBL20219396 | 0.80 | TLR8 (0.35) | TLR8TLR7NPY5RCYP3A4ALDH1A1 | |
| SCHEMBL20219386 | 0.79 | SCN9A (0.36) | TLR8TLR7NPY5RCYP3A4ALDH1A1 | |
| SCHEMBL20219430 | 0.79 | TLR7 (0.42) | TLR8TLR7CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL15469746 | 0.79 | TLR8 (0.41) | TLR8TLR7CYP1A2CYP2D6CASP6 | |
| SCHEMBL20219381 | 0.78 | TLR8 (0.34) | TLR8TLR7NPY5RCYP3A4ALDH1A1 | |
| SCHEMBL20219471 | 0.78 | NPSR1 (0.44) | TLR8TLR7CYP1A2CYP2D6CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |