Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 10/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20219381 | 0.92 | TLR8 (0.34) | TLR8TLR7ALDH1A1POLBCYP3A4 | |
| SCHEMBL15470345 | 0.87 | L3MBTL1 (0.46) | TLR8TLR7L3MBTL1 | |
| SCHEMBL23472526 | 0.84 | TLR8 (0.47) | TLR8TLR7ALDH1A1POLBCYP3A4 | |
| SCHEMBL20219328 | 0.83 | ATP4A (0.39) | SCN9ATLR8TLR7TSHR | |
| SCHEMBL20219430 | 0.83 | TLR7 (0.42) | TLR8TLR7ALDH1A1CYP3A4L3MBTL1 | |
| SCHEMBL23472288 | 0.82 | TLR8 (0.38) | TLR8TLR7CYP3A4L3MBTL1KDM4E | |
| SCHEMBL20219396 | 0.82 | TLR8 (0.35) | TLR8TLR7ALDH1A1POLBCYP3A4 | |
| SCHEMBL20219543 | 0.79 | TLR8 (0.47) | TLR8TLR7ALDH1A1POLBCYP3A4 | |
| SCHEMBL23472109 | 0.79 | TLR8 (0.38) | TLR8TLR7ALDH1A1CYP3A4L3MBTL1 | |
| SCHEMBL20219723 | 0.77 | ALDH1A1 (0.38) | TLR8TLR7ALDH1A1POLBCRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |