Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13195704 | 0.86 | TLR8 (0.58) | TLR8TLR7L3MBTL1 | |
| SCHEMBL23472288 | 0.85 | TLR8 (0.38) | TLR8TLR7CYP3A4L3MBTL1NPSR1 | |
| SCHEMBL20219396 | 0.85 | TLR8 (0.35) | TLR8TLR7CYP3A4ALDH1A1POLB | |
| SCHEMBL20219386 | 0.84 | SCN9A (0.36) | TLR8TLR7CYP3A4ALDH1A1POLB | |
| SCHEMBL20219381 | 0.83 | TLR8 (0.34) | TLR8TLR7CYP3A4ALDH1A1POLB | |
| SCHEMBL20219723 | 0.82 | ALDH1A1 (0.38) | TLR8TLR7ALDH1A1POLB | |
| SCHEMBL20219543 | 0.82 | TLR8 (0.47) | TLR8TLR7CYP3A4ALDH1A1POLB | |
| SCHEMBL23472109 | 0.82 | TLR8 (0.38) | TLR8TLR7CYP3A4ALDH1A1TSHR | |
| SCHEMBL13195128 | 0.82 | TLR8 (0.62) | TLR8TLR7L3MBTL1 | |
| SCHEMBL20219572 | 0.80 | CYP2D6 (0.43) | TLR8TLR7CYP3A4ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |