Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15470024 | 0.88 | TLR7 (0.51) | TLR7TLR8KDM4EALDH1A1HPGD | |
| SCHEMBL20219428 | 0.85 | TLR7 (0.40) | TLR7TLR8KDM4EALDH1A1HPGD | |
| SCHEMBL23472560 | 0.83 | CYP3A4 (0.46) | TLR7TLR8KDM4EALDH1A1HPGD | |
| SCHEMBL20219386 | 0.83 | SCN9A (0.36) | TLR7TLR8KDM4EALDH1A1HPGD | |
| SCHEMBL20219328 | 0.82 | ATP4A (0.39) | TLR7TLR8 | |
| SCHEMBL20219387 | 0.80 | CYP1A2 (0.45) | TLR7TLR8CYP1A2CYP2D6L3MBTL1 | |
| SCHEMBL20219381 | 0.80 | TLR8 (0.34) | TLR7TLR8KDM4EALDH1A1HPGD | |
| SCHEMBL23472288 | 0.79 | TLR8 (0.38) | TLR7TLR8KDM4ENPSR1L3MBTL1 | |
| SCHEMBL23472466 | 0.79 | CYP1A2 (0.45) | TLR7TLR8ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL20219543 | 0.79 | TLR8 (0.47) | TLR7TLR8ALDH1A1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |