Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.84 |
| ▸ | DRD2 | P14416 | 6/20 | 0.84 |
| ▸ | DRD3 | P35462 | 6/20 | 0.84 |
| ▸ | DRD4 | P21917 | 4/20 | 0.84 |
| ▸ | HTR2A | P28223 | 2/20 | 0.84 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.84 |
| ▸ | HTR2B | P41595 | 2/20 | 0.84 |
| ▸ | DRD1 | P21728 | 2/20 | 0.84 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.84 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.84 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.84 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.84 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.84 |
| ▸ | CNR1 | P21554 | 1/20 | 0.84 |
| ▸ | ACHE | P22303 | 1/20 | 0.84 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.84 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.84 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.84 |
| ▸ | HRH1 | P35367 | 1/20 | 0.84 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021032 | 1.00 | HTR1A (0.84) | HTR1ADRD2DRD3DRD4HTR2A | |
| SCHEMBL2021033 | 1.00 | HTR1A (0.84) | HTR1ADRD2DRD3DRD4HTR2A | |
| Rotigotine SCHEMBL1088585 | 0.92 | DRD2 (1.00) | HTR1ADRD2DRD3DRD4HTR2A | |
| Rotigotine SCHEMBL50425 | 0.92 | DRD2 (1.00) | HTR1ADRD2DRD3DRD4HTR2A | |
| Rotigotine SCHEMBL29354493 | 0.92 | DRD2 (1.00) | HTR1ADRD2DRD3DRD4HTR2A | |
| Rotigotine SCHEMBL9405994 | 0.92 | DRD2 (1.00) | HTR1ADRD2DRD3DRD4HTR2A | |
| Rotigotine SCHEMBL30200958 | 0.92 | DRD2 (1.00) | HTR1ADRD2DRD3DRD4HTR2A | |
| Rotigotine SCHEMBL2597403 | 0.91 | DRD2 (0.98) | HTR1ADRD2DRD3DRD4HTR2A | |
| Rotigotine SCHEMBL15970012 | 0.91 | DRD2 (0.98) | HTR1ADRD2DRD3DRD4HTR2A | |
| Rotigotine SCHEMBL2597402 | 0.91 | DRD2 (0.98) | HTR1ADRD2DRD3DRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516383-B1 | NEW AMINOTETRALINE DERIVATIVES | GMEINER PETER (DE) | 2017-05-03 | — | — | EP | claimed |
| US-8691839-B2 | Aminotetraline derivatives | GMEINER PETER (DE) | 2014-04-08 | — | — | US | claimed |
| US-20130331429-A1 | AMINOTETRALINE DERIVATIVES | GMEINER PETER (DE) | 2013-12-12 | — | — | US | claimed |
| US-8586603-B2 | Aminotetraline derivatives | GMEINER PETER (DE) | 2013-11-19 | — | — | US | claimed |
| US-20120277262-A1 | NEW AMINOTETRALINE DERIVATIVES | GMEINER PETER (DE) | 2012-11-01 | — | — | US | claimed |
| EP-2516383-A1 | NEW AMINOTETRALINE DERIVATIVES | Gmeiner, Peter (DE) | 2012-10-31 | — | — | EP | claimed |
| WO-2011076708-A1 | NEW AMINOTETRALINE DERIVATIVES | GMEINER PETER (DE) | 2011-06-30 | — | — | WO | claimed |
| EP-2338873-A1 | New aminotetraline derivatives | Gmeiner, Peter (DE) | 2011-06-29 | — | — | EP | claimed |
| EP-2516383-B1 | NEW AMINOTETRALINE DERIVATIVES | GMEINER PETER (DE) | 2017-05-03 | — | — | EP | disclosed |
| US-8691839-B2 | Aminotetraline derivatives | GMEINER PETER (DE) | 2014-04-08 | — | — | US | disclosed |
| US-20130331429-A1 | AMINOTETRALINE DERIVATIVES | GMEINER PETER (DE) | 2013-12-12 | — | — | US | disclosed |
| US-8586603-B2 | Aminotetraline derivatives | GMEINER PETER (DE) | 2013-11-19 | — | — | US | disclosed |
| US-20120277262-A1 | NEW AMINOTETRALINE DERIVATIVES | GMEINER PETER (DE) | 2012-11-01 | — | — | US | disclosed |
| EP-2516383-A1 | NEW AMINOTETRALINE DERIVATIVES | Gmeiner, Peter (DE) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076708-A1 | NEW AMINOTETRALINE DERIVATIVES | GMEINER PETER (DE) | 2011-06-30 | — | — | WO | disclosed |
| EP-2338873-A1 | New aminotetraline derivatives | Gmeiner, Peter (DE) | 2011-06-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277262-A1 | NEW AMINOTETRALINE DERIVATIVES | AADAT, ABAT, AANAT | HTR1A 159/4885DRD2 946/4885DRD3 1150/4885 |
| US-20130331429-A1 | AMINOTETRALINE DERIVATIVES | AADAT, ABAT, SLC1A2 | HTR1A 122/4885DRD2 415/4885DRD3 673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.