Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 2/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
| ▸ | DRD1 | P21728 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 3/20 | 0.35 |
| ▸ | DRD5 | P21918 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13235229 | 0.89 | MPL (0.34) | MPLRARBDRD2DRD3DRD1 | |
| SCHEMBL20061708 | 0.81 | RARB (0.43) | RARBDRD2DRD3DRD1DRD4 | |
| SCHEMBL13198676 | 0.79 | RARB (0.38) | RARBDRD2DRD3DRD1DRD4 | |
| SCHEMBL20023230 | 0.79 | CTSS (0.39) | MPLRARBFFAR4GABRA1GABRB2 | |
| SCHEMBL29150477 | 0.78 | DRD2 (0.36) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL2942703 | 0.78 | MCL1 (0.41) | RARBDRD2DRD3DRD1DRD4 | |
| SCHEMBL29873595 | 0.78 | GABRA1 (0.42) | MPLRARBFFAR4GABRA1GABRB2 | |
| SCHEMBL17616201 | 0.78 | GABRA1 (0.46) | MPLRARBFFAR4GABRA1GABRB2 | |
| SCHEMBL3437380 | 0.78 | GABRA1 (0.42) | MPLRARBFFAR4GABRA1GABRB2 | |
| SCHEMBL28328524 | 0.77 | DGAT1 (0.38) | MPLFFAR4GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018100019-A1 | THIOETHER-COMPOUNDS | MERCK PATENT GMBH (DE) | 2018-06-07 | — | — | WO | disclosed |