SCHEMBL20228293

SCHEMBL20228293

Cc1ccc(-c2ccc(C#Cc3cc(F)c(SC#N)c(F)c3)cc2)cc1

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.36
CYP2A6 P11509 1/20 0.36
AR P10275 1/20 0.35
MYC P01106 1/20 0.35
WDR5 P61964 1/20 0.35
GRM5 P41594 2/20 0.34
KCNH2 Q12809 2/20 0.34
CYP11B1 P15538 2/20 0.33
CYP11B2 P19099 2/20 0.33
CA12 O43570 2/20 0.33
CA1 P00915 2/20 0.33
CA2 P00918 2/20 0.33
CA9 Q16790 2/20 0.33
KIF11 P52732 1/20 0.33
FFAR1 O14842 1/20 0.31
GRM4 Q14833 2/20 0.30
ERBB2 P04626 1/20 0.30
KDM1A O60341 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21399529 0.95 ALDH1A1 (0.39) ALDH1A1CYP2A6MYCWDR5GRM5
SCHEMBL19465072 0.95 ALDH1A1 (0.39) ALDH1A1CYP2A6MYCWDR5GRM5
SCHEMBL21396344 0.94 ALDH1A1 (0.36) ALDH1A1CYP2A6ARMYCWDR5
SCHEMBL24296675 0.88 KDM1A (0.35) GRM5GRM4KDM1A
SCHEMBL18626195 0.86 CYP1A1 (0.41) GRM5KCNH2CYP11B1CYP11B2KIF11
SCHEMBL18499523 0.85 CYP11B1 (0.40) ALDH1A1CYP2A6ARMYCWDR5
SCHEMBL20228237 0.85 CYP11B1 (0.40) ALDH1A1CYP2A6ARMYCWDR5
SCHEMBL24940659 0.85 KIF11 (0.33) KIF11
SCHEMBL26871190 0.85 AKR1C2 (0.33) ALDH1A1CYP2A6ARMYCWDR5
SCHEMBL20228301 0.84 ALDH1A1 (0.35) ALDH1A1CYP2A6ARMYCWDR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240072425-A1 AROMATIC ISOTHIOCYANATES MERCK PATENT GMBH (DE) 2024-02-29 US disclosed
US-20230235228-A1 LIQUID CRYSTAL (LC) COMPOSITION WITH EXTREMELY-LOW DIELECTRIC LOSS AND HIGH-FREQUENCY COMPONENT INCLUDING SAME XI'AN MODERN CHEMISTRY RESEARCH INSTITUTE (CN) 2023-07-27 US disclosed
EP-4137552-A1 LIQUID CRYSTAL COMPOSITION HAVING EXTREMELY LOW DIELECTRIC LOSS, AND HIGH-FREQUENCY COMPONENT COMPRISING SAME Xi'an Modern Chemistry Research Institute (CN) 2023-02-22 EP disclosed
US-20230025385-A1 FLUORINATED AROMATIC COMPOUNDS MERCK PATENT GMBH (DE) 2023-01-26 US disclosed
US-11306251-B2 Liquid-crystalline medium MERCK PATENT GMBH (DE) 2022-04-19 US disclosed
US-11268026-B2 Liquid-crystalline medium MERCK PATENT GMBH (DE) 2022-03-08 US disclosed
US-11254874-B2 Liquid-crystalline medium and high-frequency components comprising same MERCK PATENT GMBH (DE) 2022-02-22 US disclosed
US-11180698-B2 Liquid-crystalline medium and high-frequency components comprising same MERCK PATENT GMBH (DE) 2021-11-23 US disclosed
EP-3303519-B1 LIQUID-CRYSTALLINE MEDIUM AND HIGH-FREQUENCY COMPONENTS COMPRISING SAME MERCK PATENT GMBH (DE) 2021-01-27 EP disclosed
US-20200347301-A1 Isothiocyanato-tolanes MERCK PATENT GMBH (DE) 2020-11-05 US disclosed
US-20200255737-A1 LIQUID-CRYSTALLINE MEDIUM AND HIGH-FREQUENCY COMPONENTS COMPRISING SAME MERCK PATENT GMBH (DE) 2020-08-13 US disclosed
US-20190352564-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2019-11-21 US disclosed
EP-2982730-B1 LIQUID-CRYSTALLINE MEDIUM AND HIGH-FREQUENCY COMPONENTS COMPRISING SAME MERCK PATENT GMBH (DE) 2019-10-16 EP disclosed
US-20190292458-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2019-09-26 US disclosed
US-20190292460-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2019-09-26 US disclosed
US-20180155625-A1 LIQUID-CRYSTALLINE MEDIUM AND HIGH-FREQUENCY COMPONENTS COMPRISING SAME MERCK PATENT GMBH (DE) 2018-06-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240072425-A1 AROMATIC ISOTHIOCYANATES TRPA1, TRPC1, CRY1 ALDH1A1 1864/4885CYP2A6 3225/4885AR 3489/4885
US-20230025385-A1 FLUORINATED AROMATIC COMPOUNDS TRPA1, FOXM1, AFF1 ALDH1A1 1136/4885CYP2A6 2135/4885AR 3983/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.