Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | TYR | P14679 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4655610 | 0.87 | ABCG2 (0.52) | CYP3A4MEN1KMT2ACYP2C19MAPT | |
| SCHEMBL4656458 | 0.84 | MEN1 (0.47) | CYP3A4NFKB1MEN1KMT2ACYP2C9 | |
| SCHEMBL2023234 | 0.84 | MAPT (0.44) | CYP3A4MEN1KMT2ACYP2C19MAPT | |
| SCHEMBL2022647 | 0.82 | MEN1 (0.41) | CYP3A4MEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL28098802 | 0.80 | CYP3A4 (0.48) | CYP3A4NFKB1MEN1KMT2ACYP2C9 | |
| SCHEMBL2022872 | 0.79 | CYP3A4 (0.47) | CYP3A4NFKB1MEN1KMT2ACYP2C9 | |
| SCHEMBL6906881 | 0.77 | GUSB (0.47) | MEN1KMT2AMAPTHPGDTDP1 | |
| SCHEMBL2019604 | 0.77 | CA12 (0.33) | NFKB1NFKB2RELATHRBMAOA | |
| SCHEMBL1076588 | 0.75 | MAPT (0.41) | CYP3A4NFKB1MEN1KMT2AMAPT | |
| SCHEMBL2023335 | 0.74 | MEN1 (0.47) | CYP3A4NFKB1MEN1KMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242740-A1 | AROMA COMPOSITIONS OF ALKAMIDES WITH HESPERETIN AND/OR 4-HYDROXYDIHYDROCHALCONES AND SALTS THEREOF FOR ENHANCING SWEET SENSORY IMPRESSIONS | SYMRISE GMBH & CO. KG (DE) | 2008-10-02 | — | — | US | claimed |
| EP-1818060-A1 | Cosmetic composition comprising Fadogia ancylantha extracts | ARTSANA S.p.A. (IT) | 2007-08-15 | — | — | EP | claimed |
| US-9445606-B2 | Use of 4-hydroxydihydrochalcones and their salts for enhancing an impression of sweetness | SYMRISE AG (DE) | 2016-09-20 | — | — | US | disclosed |
| US-9359622-B2 | Method for biotechnological production of dihydrochalcones | SYMRISE AG (DE) | 2016-06-07 | — | — | US | disclosed |
| US-9198451-B2 | Aroma composition to reduce or suppress undesirable bitter and astringent taste impressions of sweeteners | SYMRISE AG (DE) | 2015-12-01 | — | — | US | disclosed |
| US-8778987-B2 | Use of 4-hydroxychalcone derivatives for masking an unpleasant taste | SYMRISE AG (DE) | 2014-07-15 | — | — | US | disclosed |
| EP-2340719-B1 | Aroma composition comprising o-coumaric acid to reduce or suppress undesirable taste impressions of sweeteners | SYMRISE AG (DE) | 2014-02-19 | — | — | EP | disclosed |
| US-20140045233-A1 | Method for Biotechnological Production of Dihydrochalcones | SYMRISE AG (DE) | 2014-02-13 | — | — | US | disclosed |
| EP-2220945-B1 | Aroma composition to reduce or suppress undesirable bitter and astringent taste impressions of sweeteners | SYMRISE AG (DE) | 2013-03-27 | — | — | EP | disclosed |
| EP-2340719-A1 | Aroma composition comprising o-coumaric acid to reduce or suppress undesirable taste impressions of sweeteners | Symrise AG (DE) | 2011-07-06 | — | — | EP | disclosed |
| US-20110158919-A1 | AROMA COMPOSITION COMPRISING O-COUMARIC ACID TO REDUCE OR SUPPRESS UNDESIRABLE TASTE IMPRESSIONS OF SWEETENERS | SYMRISE AG (DE) | 2011-06-30 | — | — | US | disclosed |
| US-20100233102-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO. KG (DE) | 2010-09-16 | — | — | US | disclosed |
| EP-2220945-A1 | Aroma composition to reduce or suppress undesirable bitter and astringent taste impressions of sweeteners | Symrise GmbH & Co. KG (DE) | 2010-08-25 | — | — | EP | disclosed |
| US-20100151055-A1 | Aroma Composition to Reduce or Suppress Undesirable Bitter and Astringent Taste Impressions of Sweeteners | SYMRISE GMBH & CO. KG (DE) | 2010-06-17 | — | — | US | disclosed |
| EP-1998636-B1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO KG (DE) | 2010-05-19 | — | — | EP | disclosed |
| EP-1998636-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | Symrise GmbH & Co. KG (DE) | 2008-12-10 | — | — | EP | disclosed |
| US-20080242740-A1 | AROMA COMPOSITIONS OF ALKAMIDES WITH HESPERETIN AND/OR 4-HYDROXYDIHYDROCHALCONES AND SALTS THEREOF FOR ENHANCING SWEET SENSORY IMPRESSIONS | SYMRISE GMBH & CO. KG (DE) | 2008-10-02 | — | — | US | disclosed |
| US-20080227867-A1 | USE OF 4-HYDROXYCHALCONE DERIVATIVES FOR MASKING AN UPLEASANT TASTE | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | disclosed |
| WO-2007107596-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO. KG (DE) | 2007-09-27 | — | — | WO | disclosed |
| EP-1818060-A1 | Cosmetic composition comprising Fadogia ancylantha extracts | ARTSANA S.p.A. (IT) | 2007-08-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227867-A1 | USE OF 4-HYDROXYCHALCONE DERIVATIVES FOR MASKING AN UPLEASANT TASTE | TAS2R45, TAS2R43, TAS2R30 | CYP3A4 940/4885NFKB1 2913/4885MEN1 2094/4885 |
| US-20080242740-A1 | AROMA COMPOSITIONS OF ALKAMIDES WITH HESPERETIN AND/OR 4-HYDROXYDIHYDROCHALCONES AND SALTS THEREOF FOR ENHANCING SWEET SENSORY IMPRESSIONS | TAS2R5, TAS2R20, TAS2R40 | CYP3A4 541/4885NFKB1 3951/4885MEN1 2488/4885 |
| US-20100233102-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | TAS2R4, TAS2R1, TAS2R20 | CYP3A4 1367/4885NFKB1 3126/4885MEN1 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.