Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | SLC5A1 | P13866 | 8/20 | 0.40 |
| ▸ | SLC5A2 | P31639 | 8/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | FASN | P49327 | 1/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2019604 | 0.86 | CA12 (0.33) | SLC5A1SLC5A2MAOAMAOB | |
| SCHEMBL2023110 | 0.82 | CYP3A4 (0.47) | MEN1KMT2ACYP3A4MAPTCHRNA7 | |
| SCHEMBL2493332 | 0.78 | MEN1 (0.42) | MEN1KMT2ACYP3A4MAPTCHRNA7 | |
| SCHEMBL27084458 | 0.77 | MEN1 (0.41) | MEN1KMT2ACYP3A4MAPTCHRNA7 | |
| SCHEMBL31437614 | 0.77 | — | — | |
| SCHEMBL5084410 | 0.77 | MAOA (0.45) | MEN1KMT2ACYP3A4MAPTSLC5A1 | |
| SCHEMBL2023234 | 0.76 | MAPT (0.44) | MEN1KMT2ACYP3A4MAPTCHRNA7 | |
| SCHEMBL1076588 | 0.75 | MAPT (0.41) | MEN1KMT2ACYP3A4MAPTHPGD | |
| SCHEMBL2020902 | 0.72 | SLC5A1 (0.43) | MEN1KMT2ACYP3A4MAPTCHRNA7 | |
| SCHEMBL7080592 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9687517-B2 | Methods and compositions for treating skin | ELC MANAGEMENT LLC (US) | 2017-06-27 | — | — | US | claimed |
| US-20160106795-A9 | Methods and Compositions for Treating Skin | ELC MANAGEMENT, LLC (US) | 2016-04-21 | — | — | US | claimed |
| US-20150132401-A1 | Methods and Compositions for Treating Skin | ELC MANAGEMENT, LLC (US) | 2015-05-14 | — | — | US | claimed |
| US-20080242740-A1 | AROMA COMPOSITIONS OF ALKAMIDES WITH HESPERETIN AND/OR 4-HYDROXYDIHYDROCHALCONES AND SALTS THEREOF FOR ENHANCING SWEET SENSORY IMPRESSIONS | SYMRISE GMBH & CO. KG (DE) | 2008-10-02 | — | — | US | claimed |
| US-9782448-B2 | Methods and compositions for treating skin | ELC MANAGEMENT LLC (US) | 2017-10-10 | — | — | US | disclosed |
| US-9687517-B2 | Methods and compositions for treating skin | ELC MANAGEMENT LLC (US) | 2017-06-27 | — | — | US | disclosed |
| US-9445606-B2 | Use of 4-hydroxydihydrochalcones and their salts for enhancing an impression of sweetness | SYMRISE AG (DE) | 2016-09-20 | — | — | US | disclosed |
| US-20160106795-A9 | Methods and Compositions for Treating Skin | ELC MANAGEMENT, LLC (US) | 2016-04-21 | — | — | US | disclosed |
| US-9198451-B2 | Aroma composition to reduce or suppress undesirable bitter and astringent taste impressions of sweeteners | SYMRISE AG (DE) | 2015-12-01 | — | — | US | disclosed |
| US-20150132401-A1 | Methods and Compositions for Treating Skin | ELC MANAGEMENT, LLC (US) | 2015-05-14 | — | — | US | disclosed |
| US-8778987-B2 | Use of 4-hydroxychalcone derivatives for masking an unpleasant taste | SYMRISE AG (DE) | 2014-07-15 | — | — | US | disclosed |
| US-20140161898-A1 | Methods and Compositions for Treating Skin | ELC MANAGEMENT, LLC (US) | 2014-06-12 | — | — | US | disclosed |
| EP-2220945-A1 | Aroma composition to reduce or suppress undesirable bitter and astringent taste impressions of sweeteners | Symrise GmbH & Co. KG (DE) | 2010-08-25 | — | — | EP | disclosed |
| US-20100151055-A1 | Aroma Composition to Reduce or Suppress Undesirable Bitter and Astringent Taste Impressions of Sweeteners | SYMRISE GMBH & CO. KG (DE) | 2010-06-17 | — | — | US | disclosed |
| EP-1998636-B1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO KG (DE) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009082511-A1 | METHODS AND COMPOSITIONS FOR TREATING SKIN | ELC MANAGEMENT LLC (US) | 2009-07-02 | — | — | WO | disclosed |
| EP-1998636-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | Symrise GmbH & Co. KG (DE) | 2008-12-10 | — | — | EP | disclosed |
| US-20080242740-A1 | AROMA COMPOSITIONS OF ALKAMIDES WITH HESPERETIN AND/OR 4-HYDROXYDIHYDROCHALCONES AND SALTS THEREOF FOR ENHANCING SWEET SENSORY IMPRESSIONS | SYMRISE GMBH & CO. KG (DE) | 2008-10-02 | — | — | US | disclosed |
| US-20080227867-A1 | USE OF 4-HYDROXYCHALCONE DERIVATIVES FOR MASKING AN UPLEASANT TASTE | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | disclosed |
| WO-2007107596-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO. KG (DE) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227867-A1 | USE OF 4-HYDROXYCHALCONE DERIVATIVES FOR MASKING AN UPLEASANT TASTE | TAS2R45, TAS2R43, TAS2R30 | MEN1 2094/4885KMT2A 3591/4885CYP3A4 940/4885 |
| US-20150132401-A1 | Methods and Compositions for Treating Skin | LTB4R2, LTB4R, CYSLTR2 | MEN1 4799/4885KMT2A 4195/4885CYP3A4 3588/4885 |
| US-20080242740-A1 | AROMA COMPOSITIONS OF ALKAMIDES WITH HESPERETIN AND/OR 4-HYDROXYDIHYDROCHALCONES AND SALTS THEREOF FOR ENHANCING SWEET SENSORY IMPRESSIONS | TAS2R5, TAS2R20, TAS2R40 | MEN1 2488/4885KMT2A 155/4885CYP3A4 541/4885 |
| US-20140161898-A1 | Methods and Compositions for Treating Skin | LTB4R2, LTB4R, CYSLTR2 | MEN1 4799/4885KMT2A 4195/4885CYP3A4 3588/4885 |
| US-20160106795-A9 | Methods and Compositions for Treating Skin | LTB4R2, LTB4R, CYSLTR2 | MEN1 4799/4885KMT2A 4195/4885CYP3A4 3588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.