Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 2/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018673 | 0.98 | DRD2 (0.32) | DRD2DRD4HRH2HRH1DRD3 | |
| SCHEMBL2200403 | 0.94 | GAA (0.32) | — | |
| SCHEMBL23800760 | 0.94 | HTR7 (0.35) | DRD2DRD3 | |
| SCHEMBL29565407 | 0.94 | HTR7 (0.35) | DRD2DRD3 | |
| SCHEMBL11995963 | 0.93 | PIK3CA (0.35) | DRD2DRD4HRH2HRH1DRD3 | |
| SCHEMBL25605060 | 0.93 | PIK3CA (0.35) | DRD2DRD4HRH2HRH1DRD3 | |
| SCHEMBL2200006 | 0.93 | ACHE (0.35) | DRD2HRH1ACHEBACE1 | |
| SCHEMBL24620699 | 0.92 | ACHE (0.35) | ACHES1PR1 | |
| SCHEMBL23800786 | 0.92 | TNK2 (0.31) | ACHE | |
| SCHEMBL29565404 | 0.92 | TNK2 (0.31) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2333028-B1 | Photochromic compounds | TRANSITIONS OPTICAL INC (US) | 2017-11-08 | — | — | EP | claimed |
| EP-2333028-A1 | Photochromic compounds | TRANSITIONS OPTICAL, INC. (US) | 2011-06-15 | — | — | EP | claimed |
| EP-1639058-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2006-03-29 | — | — | EP | claimed |
| WO-2005005570-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2005-01-20 | — | — | WO | claimed |
| US-20050004361-A1 | Thermally reversible; absorption ratio greater than 2.3 | TRANSITIONS OPTICAL LIMITED (IE) | 2005-01-06 | — | — | US | claimed |
| EP-2357217-B9 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2019-03-13 | — | — | EP | disclosed |
| EP-2357217-B1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2018-10-31 | — | — | EP | disclosed |
| EP-2360224-B1 | Photochromic compounds | TRANSITIONS OPTICAL INC (US) | 2018-10-17 | — | — | EP | disclosed |
| EP-2333028-B1 | Photochromic compounds | TRANSITIONS OPTICAL INC (US) | 2017-11-08 | — | — | EP | disclosed |
| EP-2360224-A1 | Photochromic compounds | TRANSITIONS OPTICAL, INC. (US) | 2011-08-24 | — | — | EP | disclosed |
| EP-2357217-A1 | Photochromic compounds | TRANSITIONS OPTICAL, INC. (US) | 2011-08-17 | — | — | EP | disclosed |
| EP-2333028-A1 | Photochromic compounds | TRANSITIONS OPTICAL, INC. (US) | 2011-06-15 | — | — | EP | disclosed |
| US-20080096049-A1 | capable of switching between the two states in response to at least actinic radiation; thermally reversible | TRANSITIONS OPTICAL, INC. (US) | 2008-04-24 | — | — | US | disclosed |
| US-20080096048-A1 | Thermally reversible; absorption ratio greater than 2.3 | TRANSITIONS OPTICAL, INC. (US) | 2008-04-24 | — | — | US | disclosed |
| US-7342112-B2 | Photochromic compounds | PPG INDUSTRIES OHIO, INC. (US) | 2008-03-11 | — | — | US | disclosed |
| US-20080051575-A1 | capable of switching between the two states in response to at least actinic radiation; thermally reversible | TRANSITIONS OPTICAL ,INC. (US) | 2008-02-28 | — | — | US | disclosed |
| US-20080045704-A1 | Thermally reversible; absorption ratio greater than 2.3; cell method | TRANSITIONS OPTICAL, INC. (US) | 2008-02-21 | — | — | US | disclosed |
| EP-1639058-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005005570-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2005-01-20 | — | — | WO | disclosed |
| US-20050004361-A1 | Thermally reversible; absorption ratio greater than 2.3 | TRANSITIONS OPTICAL LIMITED (IE) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045704-A1 | Thermally reversible; absorption ratio greater than 2.3; cell method | CCND3, CCND1, CCND2 | DRD2 1141/4885DRD4 816/4885HRH2 2106/4885 |
| US-20080096048-A1 | Thermally reversible; absorption ratio greater than 2.3 | CCND1, CCND3, CCND2 | DRD2 1350/4885DRD4 826/4885HRH2 2110/4885 |
| US-20080051575-A1 | capable of switching between the two states in response to at least actinic radiation; thermally reversible | CCND1, CCND2, CCNE1 | DRD2 1452/4885DRD4 1242/4885HRH2 3198/4885 |
| US-20050004361-A1 | Thermally reversible; absorption ratio greater than 2.3 | CCND1, CCND3, CCND2 | DRD2 1350/4885DRD4 826/4885HRH2 2110/4885 |
| US-20080096049-A1 | capable of switching between the two states in response to at least actinic radiation; thermally reversible | CCND1, CCND2, CCNE1 | DRD2 1452/4885DRD4 1242/4885HRH2 3198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.