SCHEMBL2200403

SCHEMBL2200403

COc1cc2c3c(c4c(c2cc1N1CCN(c2ccc(O)cc2)CC1)-c1ccccc1C4(C)C)C=CC(c1ccccc1)(c1ccc(N2CCN(c4ccccc4)CC2)cc1)O3

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.31
TYR P14679 1/20 0.31
LMNA P02545 1/20 0.30
HTT P42858 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2018673 0.96 DRD2 (0.32) MAPTLMNAHTTSMN1; SMN2
SCHEMBL2023151 0.94 DRD2 (0.31)
SCHEMBL29565404 0.92 TNK2 (0.31) MAPT
SCHEMBL23800786 0.92 TNK2 (0.31) MAPT
SCHEMBL25605060 0.92 PIK3CA (0.35) GAAMAPTLMNASMN1; SMN2
SCHEMBL11995963 0.92 PIK3CA (0.35) GAAMAPTLMNASMN1; SMN2
SCHEMBL2200006 0.92 ACHE (0.35) MAPTLMNAHTTSMN1; SMN2
SCHEMBL2237768 0.90 L3MBTL1 (0.40) MAPTLMNAHTTSMN1; SMN2
SCHEMBL25844425 0.90 STK10 (0.35) GAAMAPTLMNASMN1; SMN2
SCHEMBL20527906 0.89 DRD2 (0.36) GAAMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3367143-B1 POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME TRANSITIONS OPTICAL INC (US) 2023-01-11 EP disclosed
EP-3367143-A1 POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME Transitions Optical, Inc. (US) 2018-08-29 EP disclosed
EP-1642160-B1 POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME TRANSITIONS OPTICAL INC (US) 2018-04-11 EP disclosed
US-7978391-B2 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL, INC. (US) 2011-07-12 US disclosed
US-7847998-B2 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL, INC. (US) 2010-12-07 US disclosed
US-7505189-B2 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL, INC. (US) 2009-03-17 US disclosed
US-7471436-B2 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL, INC. (US) 2008-12-30 US disclosed
US-7466469-B2 Polarizing, photochromic devices and methods of making the same PPG INDUSTRIES OHIO, INC. (US) 2008-12-16 US disclosed
US-7457025-B2 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL, INC. (US) 2008-11-25 US disclosed
US-7429105-B2 Polarizing, photochromic devices and methods of making the same PPG INDUSTRIES OHIO, INC. (US) 2008-09-30 US disclosed
US-20070053047-A1 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL LIMITED (IE) 2007-03-08 US disclosed
US-20070053048-A1 Polirizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL LIMITED (IE) 2007-03-08 US disclosed
US-20070047055-A1 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL LIMITED (IE) 2007-03-01 US disclosed
US-20070047053-A1 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL LIMITED (IE) 2007-03-01 US disclosed
US-20070047054-A1 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL LIMITED (IE) 2007-03-01 US disclosed
US-20070041071-A1 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL LIMITED (IE) 2007-02-22 US disclosed
US-20070041073-A1 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL LIMITED (IE) 2007-02-22 US disclosed
EP-1642160-A1 POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME TRANSITIONS OPTICAL, INC. (US) 2006-04-05 EP disclosed
WO-2005006035-A1 POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME TRANSITIONS OPTICAL, INC. (US) 2005-01-20 WO disclosed
US-20050012998-A1 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL LIMITED (IE) 2005-01-20 US disclosed