Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.41 |
| ▸ | KARS1 | Q15046 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | YES1 | P07947 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021387 | 0.89 | SHMT2 (0.42) | KDM4EMAPTZAP70KARS1MEN1 | |
| SCHEMBL2022707 | 0.89 | PIK3C2B (0.47) | KDM4EMAPTZAP70KARS1L3MBTL1 | |
| SCHEMBL2023644 | 0.88 | MAPT (0.43) | KDM4EMAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL2019656 | 0.88 | SRC (0.39) | ZAP70KARS1GFER | |
| SCHEMBL2024324 | 0.88 | KMT2A (0.41) | MAPTNPSR1MEN1KMT2AMAPK1 | |
| SCHEMBL2025887 | 0.87 | TTK (0.41) | KDM4EMAPTNPSR1ZAP70KARS1 | |
| SCHEMBL2018894 | 0.86 | BRD4 (0.36) | KDM4EMAPTZAP70KARS1L3MBTL1 | |
| SCHEMBL2023645 | 0.85 | ZAP70 (0.47) | KDM4EMAPTNPSR1ZAP70KARS1 | |
| SCHEMBL2018866 | 0.85 | SMN1; SMN2 (0.42) | KDM4EMAPTZAP70KARS1ALDH1A1 | |
| SCHEMBL2025118 | 0.84 | RAB9A (0.46) | MAPTNPSR1ZAP70KARS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | ARQULE, INC. (US) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | MKI67, TP53, THPO | KDM4E 3014/4885MAPT 2493/4885NPSR1 1874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.