Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KARS1 | Q15046 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018876 | 0.88 | NPC1 (0.39) | RAB9ANPC1NPSR1SMN1; SMN2ZAP70 | |
| SCHEMBL2022707 | 0.88 | PIK3C2B (0.47) | ALDH1A1HTTLMNATP53ZAP70 | |
| SCHEMBL2021387 | 0.88 | SHMT2 (0.42) | ALDH1A1ZAP70MEN1KMT2AMAPT | |
| SCHEMBL2025887 | 0.88 | TTK (0.41) | RAB9ANPC1ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL2019861 | 0.87 | RAB9A (0.42) | RAB9ANPC1SMN1; SMN2TP53ZAP70 | |
| SCHEMBL2021403 | 0.87 | CCNE2 (0.39) | RAB9ANPC1SMN1; SMN2ZAP70MEN1 | |
| SCHEMBL2024539 | 0.87 | CRHR1 (0.40) | HTTZAP70MEN1KMT2AKARS1 | |
| SCHEMBL2017895 | 0.86 | AURKA (0.36) | RAB9ANPC1SMN1; SMN2TP53ZAP70 | |
| SCHEMBL2024818 | 0.86 | ZAP70 (0.47) | ZAP70KARS1 | |
| SCHEMBL2019653 | 0.85 | SYK (0.37) | RAB9ANPC1SMN1; SMN2ZAP70MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | ARQULE, INC. (US) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | MKI67, TP53, THPO | RAB9A 3244/4885NPC1 803/4885ALDH1A1 1473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.