Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C2B | O00750 | 2/20 | 0.47 |
| ▸ | PIK3C2G | O75747 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.40 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021387 | 0.92 | SHMT2 (0.42) | PIK3C2BPIK3C2GMAPTKDM4EKMT2A | |
| SCHEMBL2023644 | 0.91 | MAPT (0.43) | PIK3C2BPIK3C2GMAPTKDM4EKMT2A | |
| SCHEMBL2024324 | 0.91 | KMT2A (0.41) | PIK3C2BPIK3C2GMAPTKMT2ALMNA | |
| SCHEMBL2024539 | 0.90 | CRHR1 (0.40) | PIK3C2BPIK3C2GKMT2AMEN1MAPK1 | |
| SCHEMBL2023862 | 0.89 | KDM4E (0.43) | MAPTKDM4EKMT2ALMNAL3MBTL1 | |
| SCHEMBL2025118 | 0.88 | RAB9A (0.46) | MAPTKMT2ALMNAGAAMEN1 | |
| SCHEMBL14136760 | 0.82 | PIK3C2B (0.46) | PIK3C2BPIK3C2GMAPTKDM4EKMT2A | |
| SCHEMBL2019656 | 0.81 | SRC (0.39) | ZAP70KARS1 | |
| SCHEMBL2024818 | 0.81 | ZAP70 (0.47) | KDM4EZAP70KARS1 | |
| SCHEMBL2022481 | 0.80 | RXFP1 (0.42) | KMT2AGAAMEN1ZAP70KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | ARQULE, INC. (US) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | MKI67, TP53, THPO | PIK3C2B 1600/4885PIK3C2G 2848/4885MAPT 2493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.