Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16738672 | 0.88 | PDE2A (0.36) | ALDH1A1HPGDMAPK8MAPK9SMN1; SMN2 | |
| SCHEMBL20252435 | 0.88 | ALDH1A1 (0.33) | ALDH1A1MAPTHPGDMAPK8MAPK9 | |
| SCHEMBL20239274 | 0.86 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2GAAPOLBKMT2A | |
| SCHEMBL20239134 | 0.86 | PTPN1 (0.33) | ALDH1A1MAPK8MAPK9PLA2G10SMN1; SMN2 | |
| SCHEMBL20239283 | 0.86 | SMN1; SMN2 (0.34) | ALDH1A1MAPTHPGDMAPK8MAPK9 | |
| SCHEMBL20239238 | 0.85 | KDM4E (0.35) | ALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL20239308 | 0.84 | SMN1; SMN2 (0.34) | ALDH1A1PLA2G10SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL20239258 | 0.83 | PDE4B (0.34) | ALDH1A1MAPTHPGDMAPK8MAPK9 | |
| SCHEMBL16738668 | 0.75 | SMN1; SMN2 (0.43) | ALDH1A1MAPTHPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL16738676 | 0.75 | GPR119 (0.36) | ALDH1A1MAPK8MAPK9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3298001-B1 | DGAT2 INHIBITORS | LILLY CO ELI (US) | 2020-05-13 | — | — | EP | disclosed |
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | ELI LILY AND COMPANY (US) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | DGAT2, DGAT1, LCAT | ALDH1A1 1430/4885MAPT 2739/4885HPGD 2550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.