Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.70 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.70 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.66 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.66 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.61 |
| ▸ | NSD3 | Q9BZ95 | 6/20 | 0.60 |
| ▸ | NSD2 | O96028 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | PI4KA | P42356 | 1/20 | 0.56 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.56 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.56 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382916 | 0.85 | FGFR1 (0.66) | FGFR1SLC22A6ADORA2AADORA1ADORA2B | |
| SCHEMBL4364344 | 0.85 | ADORA2A (0.70) | FGFR1SLC22A6ADORA2AADORA1ADORA2B | |
| SCHEMBL1920120 | 0.83 | FGFR1 (0.67) | FGFR1SLC22A6ADORA2AADORA1ADCY5 | |
| Adefovir SCHEMBL49373 | 0.82 | FGFR1 (1.00) | FGFR1SLC22A6ADORA2AADORA1ADCY5 | |
| SCHEMBL3304318 | 0.82 | FGFR1 (0.66) | FGFR1SLC22A6ADORA2AADORA1ADCY5 | |
| Adefovir SCHEMBL29365535 | 0.82 | FGFR1 (1.00) | FGFR1SLC22A6ADORA2AADORA1ADCY5 | |
| SCHEMBL3301363 | 0.82 | FGFR1 (0.77) | FGFR1SLC22A6ADORA2AADORA1ADORA2B | |
| SCHEMBL11222112 | 0.82 | ADORA2A (0.80) | ADORA2AADORA1ADCY5ADORA2BNSD3 | |
| SCHEMBL7165319 | 0.82 | NSD3 (0.71) | FGFR1SLC22A6ADORA2AADORA1ADORA2B | |
| SCHEMBL23559498 | 0.82 | PI4KA (0.63) | FGFR1SLC22A6ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075747-A1 | THERAPEUTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-06-23 | — | — | WO | disclosed |