Sugi Predict

Sugi Predict / Compounds / SCHEMBL4364344

SCHEMBL4364344

SCHEMBL4364344

CCOCCn1cnc2c(N)ncnc21

nearest known ligand 0.70

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ADORA2A P29274 6/20 0.70
▸ ADORA1 P30542 3/20 0.70
▸ ADORA2B P29275 1/20 0.70
▸ FGFR1 P11362 1/20 0.66
▸ SLC22A6 Q4U2R8 1/20 0.66
▸ PI4KA P42356 2/20 0.65
▸ PI4K2B Q8TCG2 2/20 0.65
▸ PI4K2A Q9BTU6 2/20 0.65
▸ PI4KB Q9UBF8 2/20 0.65
▸ NSD3 Q9BZ95 7/20 0.64
▸ LMNA P02545 2/20 0.64
▸ SMN1; SMN2 Q16637 2/20 0.64
▸ HPGD P15428 1/20 0.61
▸ NSD2 O96028 6/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28195884 0.92 ADORA2A (0.72) ADORA2AADORA1ADORA2BFGFR1SLC22A6
Water SCHEMBL28104849 0.90 ADORA2A (0.70) ADORA2AADORA1ADORA2BFGFR1SLC22A6
SCHEMBL7164284 0.86 FGFR1 (0.60) ADORA2AADORA1ADORA2BFGFR1SLC22A6
SCHEMBL2023978 0.85 FGFR1 (0.70) ADORA2AADORA1ADORA2BFGFR1SLC22A6
SCHEMBL382916 0.85 FGFR1 (0.66) ADORA2AADORA1ADORA2BFGFR1SLC22A6
SCHEMBL3421828 0.85 ADORA2A (0.62) ADORA2AADORA1ADORA2BFGFR1SLC22A6
SCHEMBL7165319 0.85 NSD3 (0.71) ADORA2AADORA1ADORA2BFGFR1SLC22A6
SCHEMBL9885880 0.85 ADORA2A (0.69) ADORA2AADORA1ADORA2BPI4KAPI4K2B
SCHEMBL23559498 0.85 PI4KA (0.63) ADORA2AADORA1ADORA2BFGFR1SLC22A6
SCHEMBL15257630 0.85 FGFR1 (0.62) ADORA2AADORA1ADORA2BFGFR1SLC22A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2744810-B2 TENOFOVIR ALAFENAMIDE HEMIFUMARATE GILEAD SCIENCES INC (US) 2023-09-13 — — EP disclosed
US-20230159574-A1 BENZYLOXY PHOSPH(ON)ATE COMPOUNDS CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2023-05-25 — — US disclosed
US-20210219546-A1 METHODS OF TREATING CROP PLANTS ALTER DOMUS US LLC 2021-07-22 — — US disclosed
EP-3831832-A1 TENOFOVIR ALAFENAMIDE HEMIFUMARATE Gilead Sciences, Inc. (US) 2021-06-09 — — EP disclosed
EP-3294052-A1 METHODS OF TREATING CROP PLANTS Agrofresh, Inc. (US) 2018-03-21 — — EP disclosed
WO-2017203395-A1 CRYSTALLINE FORMS OF TENOFOVIR ALAFENAMIDE HEMI FUMARATE SHILPA MEDICARE LIMITED (IN) 2017-11-30 — — WO disclosed
US-9624249-B2 Nucleoside kinase bypass compositions and methods MERCK SHARP & DOHME CORP. (US) 2017-04-18 — — US disclosed
WO-2016182995-A1 METHODS OF TREATING CROP PLANTS AGROFRESH INC (US) 2016-11-17 — — WO disclosed
US-20160129122-A1 FATTY ACID ANTIVIRAL CONJUGATES AND THEIR USES CATABASIS PHARMACEUTICALS, INC. 2016-05-12 — — US disclosed
US-20150315221-A1 NUCLEOSIDE KINASE BYPASS COMPOSITIONS AND METHODS MERCK SHARP & DOHME CORP. (US) 2015-11-05 — — US disclosed
WO-2014088923-A1 NUCLEOSIDE KINASE BYPASS COMPOSITIONS AND METHODS MERCK SHARP & DOHME CORP. (US) 2014-06-12 — — WO disclosed
US-20130244966-A1 FATTY ACID ANTIVIRAL CONJUGATES AND THEIR USES CATABASIS PHARMACEUTICALS, INC. (US) 2013-09-19 — — US disclosed
EP-2070419-A1 A liquid composition for treating plants Rohm and Haas Company (US) 2009-06-17 — — EP disclosed
EP-1856976-A2 Contacting crop plants with compositions Rohm and Haas Company (US) 2007-11-21 — — EP disclosed
US-20070265166-A1 Contacting crop plants with compositions ALTER DOMUS US LLC 2007-11-15 — — US disclosed
US-20070117720-A1 Compositions with cyclopropenes AGROFRESH, INC. 2007-05-24 — — US disclosed
EP-1787513-A2 Compositions with cyclopropenes Rohm and Haas Company (US) 2007-05-23 — — EP disclosed
US-20060160704-A1 Plant growth regulation BASEL RICHARD M 2006-07-20 — — US disclosed
EP-1680960-A1 Plant growth regulation Rohm and Haas Company (US) 2006-07-19 — — EP disclosed
WO-1998011121-A1 BIOLOGICALLY ACTIVE PHOSPHOTRIESTER-TYPE COMPOUNDS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 1998-03-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130244966-A1 FATTY ACID ANTIVIRAL CONJUGATES AND THEIR USES FABP1, FABP2, HAVCR2 ADORA2A 645/4885ADORA1 1140/4885ADORA2B 2001/4885
US-20070265166-A1 Contacting crop plants with compositions PIN1, MYB, CROCC ADORA2A 4334/4885ADORA1 4328/4885ADORA2B 4460/4885
US-20230159574-A1 BENZYLOXY PHOSPH(ON)ATE COMPOUNDS PYGL, GOT2, ALPI ADORA2A 425/4885ADORA1 1154/4885ADORA2B 488/4885
US-20060160704-A1 Plant growth regulation MYB, SLTM, YAP1 ADORA2A 4420/4885ADORA1 3927/4885ADORA2B 4539/4885
US-20150315221-A1 NUCLEOSIDE KINASE BYPASS COMPOSITIONS AND METHODS DCK, DTYMK, TK1 ADORA2A 353/4885ADORA1 1092/4885ADORA2B 773/4885
US-20160129122-A1 FATTY ACID ANTIVIRAL CONJUGATES AND THEIR USES FABP1, FABP2, HAVCR2 ADORA2A 645/4885ADORA1 1140/4885ADORA2B 2001/4885
US-20070117720-A1 Compositions with cyclopropenes MYB, OSBP, FAR1 ADORA2A 1688/4885ADORA1 1382/4885ADORA2B 1014/4885
US-20210219546-A1 METHODS OF TREATING CROP PLANTS CYCS, NOP2, CNPY3 ADORA2A 4060/4885ADORA1 4027/4885ADORA2B 4032/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.