SCHEMBL20240263

SCHEMBL20240263

COc1c(C(C)(C)C)cc(-c2cccc3c2C=C(C)C3)cc1C(C)(C)C

nearest known ligand 0.37

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 3/20 0.37
PTGS1 P23219 1/20 0.34
TNFRSF1A P19438 1/20 0.33
CYP3A4 P08684 3/20 0.32
ALDH1A1 P00352 1/20 0.31
TSHR P16473 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
EGFR P00533 1/20 0.30
ERBB2 P04626 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27171027 0.91 PTGS2 (0.32) PTGS2PTGS1
SCHEMBL16829412 0.87 PTGS2 (0.35) PTGS2PTGS1TNFRSF1ACYP3A4EGFR
SCHEMBL16829408 0.84 PTGS2 (0.36) PTGS2PTGS1TNFRSF1ACYP3A4
SCHEMBL16829568 0.80 PTGS2 (0.36) PTGS2PTGS1TNFRSF1ACYP3A4ALDH1A1
SCHEMBL28724498 0.79 ALOX5AP (0.32) PTGS2
SCHEMBL6031753 0.79 RXRB (0.36) ALDH1A1
SCHEMBL29594786 0.79 RXRB (0.36) ALDH1A1
SCHEMBL16829504 0.78 PTGS2 (0.37) PTGS2PTGS1TNFRSF1ACYP3A4EGFR
SCHEMBL6150740 0.77 RXRB (0.35)
SCHEMBL18280777 0.76 PTGS2 (0.37) PTGS2PTGS1TNFRSF1ACYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12195563-B2 Polyolefin-based ionomers and production thereof EXXONMOBIL CHEMICAL PATENTS INC. (US) 2025-01-14 US disclosed
US-20240084056-A1 Polyolefin-Based Ionomers and Production Thereof EXXONMOBIL CHEMICAL PATENTS INC (US) 2024-03-14 US disclosed
EP-4271718-A1 POLYOLEFIN-BASED IONOMERS AND PRODUCTION THEREOF ExxonMobil Chemical Patents Inc. (US) 2023-11-08 EP disclosed
US-11492425-B2 Metallocene catalyst compositions and polymerization process therewith EXXONMOBIL CHEMICAL PATENTS INC. (US) 2022-11-08 US disclosed
US-20220213241-A1 Polyolefin-Based Ionomers and Production Thereof EXXONMOBIL CHEMICAL PATENTS INC (US) 2022-07-07 US disclosed
WO-2022146634-A1 POLYOLEFIN-BASED IONOMERS AND PRODUCTION THEREOF EXXONMOBIL CHEMICAL PATENTS INC. (US) 2022-07-07 WO disclosed
US-11001657-B2 Unbridged indacenyl metallocenes EXXONMOBIL CHEMICAL PATENTS INC. (US) 2021-05-11 US disclosed
US-11001657-B2 Unbridged indacenyl metallocenes EXXONMOBIL CHEMICAL PATENTS INC. (US) 2021-05-11 US disclosed
US-10723821-B2 Supported metallocene catalyst systems for polymerization EXXONMOBIL CHEMICAL PATENTS INC. (US) 2020-07-28 US disclosed
CN-111225927-A Unbridged indacenyl metallocenes 埃克森美孚化学专利公司 2020-06-02 CN disclosed
US-20190119418-A1 Unbridged Indacenyl Metallocenes EXXONMOBIL CHEMICAL PATENTS INC. 2019-04-25 US disclosed
US-20190119418-A1 Unbridged Indacenyl Metallocenes EXXONMOBIL CHEMICAL PATENTS INC. 2019-04-25 US disclosed
CN-109312013-A Metallocene catalyst compositions and the polymerization for using it 埃克森美孚化学专利公司 2019-02-05 CN disclosed
US-20180162964-A1 Supported Metallocene Catalyst Systems for Polymerization EXXONMOBIL CHEMICAL PATENTS INC. 2018-06-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10723821-B2 Supported metallocene catalyst systems for polymerization LATS1, PCNA, RAD52 PTGS2 636/4885PTGS1 1006/4885TNFRSF1A 1711/4885
US-11001657-B2 Unbridged indacenyl metallocenes MT-ND4L, MT-ND4, ACSL4 PTGS2 1259/4885PTGS1 1676/4885TNFRSF1A 2257/4885
US-11492425-B2 Metallocene catalyst compositions and polymerization process therewith TERT, MDM4, PCBP1 PTGS2 2131/4885PTGS1 3180/4885TNFRSF1A 3509/4885
US-20180162964-A1 Supported Metallocene Catalyst Systems for Polymerization LATS1, PCNA, RAD52 PTGS2 636/4885PTGS1 1006/4885TNFRSF1A 1711/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.