Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.49 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16440176 | 0.90 | HSD11B1 (0.51) | L3MBTL3L3MBTL1ACVR1BMPR1BBMPR1A | |
| SCHEMBL23107276 | 0.86 | MAP4K4 (0.47) | L3MBTL3L3MBTL1ACVR1BMPR1BBMPR1A | |
| SCHEMBL255401 | 0.86 | MAPT (0.55) | L3MBTL1MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL20248039 | 0.85 | L3MBTL3 (0.64) | L3MBTL3L3MBTL1MBTD1HRH3ALDH1A1 | |
| SCHEMBL18054450 | 0.84 | TRPV6 (0.49) | L3MBTL3L3MBTL1HRH3MEN1KMT2A | |
| SCHEMBL16427580 | 0.84 | CHRNB2 (0.51) | L3MBTL3L3MBTL1ACVR1BMPR1BBMPR1A | |
| SCHEMBL29437377 | 0.84 | L3MBTL3 (0.50) | L3MBTL3L3MBTL1ACVR1BMPR1BBMPR1A | |
| SCHEMBL2723240 | 0.84 | L3MBTL3 (0.50) | L3MBTL3L3MBTL1ACVR1BMPR1BBMPR1A | |
| SCHEMBL23103536 | 0.83 | L3MBTL3 (0.46) | L3MBTL3L3MBTL1ACVR1BMPR1BBMPR1A | |
| SCHEMBL23108989 | 0.83 | L3MBTL3 (0.46) | L3MBTL3L3MBTL1ACVR1BMPR1BBMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018106729-A1 | PRESERVATION OF IMMUNE RESPONSE DURING CHEMOTHERAPY REGIMENS | G1 THERAPEUTICS, INC. (US) | 2018-06-14 | — | — | WO | disclosed |