Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.78 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.70 |
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 7/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.68 |
| ▸ | HPGD | P15428 | 6/20 | 0.68 |
| ▸ | GAA | P10253 | 5/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.59 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.59 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20248968 | 0.88 | MAPT (1.00) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL20248965 | 0.85 | MAPT (0.78) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL20248975 | 0.85 | MAPT (0.78) | MAPTANO1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL20248969 | 0.81 | ALDH1A1 (1.00) | MAPTANO1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1622732 | 0.81 | ALDH1A1 (1.00) | MAPTANO1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL20248980 | 0.80 | ALDH1A1 (0.98) | MAPTANO1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8291524 | 0.77 | ALDH1A1 (0.49) | MAPTANO1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL13210588 | 0.77 | HPGD (0.68) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL20248966 | 0.76 | ALDH1A1 (0.68) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3280513 | 0.76 | ALDH1A1 (0.56) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10253035-B2 | Eis inhibitors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2019-04-09 | — | — | US | disclosed |
| US-20180162867-A1 | EIS INHIBITORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2018-06-14 | — | — | US | disclosed |
| US-20180162867-A1 | EIS INHIBITORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162867-A1 | EIS INHIBITORS | EP300, ACAT1, ACAT2 | MAPT 4313/4885ANO1 3988/4885ALDH1A1 1232/4885 |
| US-10253035-B2 | Eis inhibitors | EP300, ACAT1, ACAT2 | MAPT 4313/4885ANO1 3988/4885ALDH1A1 1232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.