Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | CCR9 | P51686 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GPR4 | P46093 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291305 | 0.82 | CHRM1 (0.44) | CDK4CDK6SMN1; SMN2GPR4KCNH2 | |
| SCHEMBL20249153 | 0.82 | ALDH1A1 (0.51) | CCR9SMN1; SMN2ALDH1A1CHRNA1CHRNA7 | |
| SCHEMBL20249210 | 0.81 | L3MBTL1 (0.49) | CCR9KCNH2 | |
| SCHEMBL20038452 | 0.80 | CDK4 (0.41) | CDK4CDK6SMN1; SMN2ALDH1A1GPR4 | |
| SCHEMBL18291271 | 0.80 | CDK4 (0.41) | CDK4CDK6SMN1; SMN2ALDH1A1GPR4 | |
| SCHEMBL20249280 | 0.79 | NPC1 (0.38) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL20224126 | 0.79 | CXCR4 (0.49) | PPARDCXCR4 | |
| SCHEMBL20249150 | 0.79 | SMN1; SMN2 (0.62) | CCR9SMN1; SMN2ALDH1A1CHRNA1CHRNA7 | |
| SCHEMBL20037443 | 0.79 | CDK4 (0.50) | CDK4CDK6SMN1; SMN2ALDH1A1GPR4 | |
| SCHEMBL20249207 | 0.78 | CYP11B2 (0.40) | CCR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | TEIJIN PHARMA LIMITED (JP) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | CDK4, CDK6, CDK16 | CDK4 1/4885CDK6 2/4885CCR9 2183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.