Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12228951 | 0.92 | ALDH1A1 (0.39) | ALDH1A1KDM4ERAB9AKMT2APOLB | |
| SCHEMBL20249210 | 0.84 | L3MBTL1 (0.49) | KMT2AMEN1NPC1ACACBL3MBTL1 | |
| SCHEMBL20037444 | 0.83 | RAB9A (0.44) | ALDH1A1KDM4ERAB9AKMT2AMEN1 | |
| SCHEMBL20249205 | 0.82 | SIGMAR1 (0.41) | KMT2APOLBPDK2TSHRMOGAT2 | |
| SCHEMBL20249189 | 0.81 | PDK2 (0.47) | ALDH1A1KDM4EKMT2APOLBTDP1 | |
| SCHEMBL18291622 | 0.81 | RAB9A (0.41) | ALDH1A1KDM4ERAB9AKMT2APOLB | |
| SCHEMBL20037894 | 0.81 | ALDH1A1 (0.43) | ALDH1A1KDM4ERAB9AKMT2AMEN1 | |
| SCHEMBL13946711 | 0.78 | RAB9A (0.55) | ALDH1A1RAB9AKMT2AMEN1NPC1 | |
| SCHEMBL20249194 | 0.78 | PDK2 (0.49) | KDM4ERAB9AKMT2APOLBMEN1 | |
| SCHEMBL16190278 | 0.75 | ALDH1A1 (0.44) | ALDH1A1KDM4ERAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | TEIJIN PHARMA LIMITED (JP) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | CDK4, CDK6, CDK16 | ALDH1A1 944/4885KDM4E 470/4885RAB9A 2154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.