Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.47 |
| ▸ | HTR2B | P41595 | 3/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 5/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.47 |
| ▸ | HTR1D | P28221 | 2/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.47 |
| ▸ | HTR5A | P47898 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 5/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20249187 | 0.84 | HTR6 (0.45) | HTR6HTR2BADRB2ADRA2AHTR2C | |
| SCHEMBL2366124 | 0.81 | ADRB1 (0.50) | HTR6HTR2BADRB2HTR2CHRH1 | |
| SCHEMBL21815399 | 0.78 | CHRNB2 (0.47) | HTR6HTR2BADRB2HTR1AHTR7 | |
| SCHEMBL20037462 | 0.78 | ADRB1 (0.47) | HTR6HTR2BADRB2HTR2CHTR1A | |
| SCHEMBL18291344 | 0.78 | NCF1 (0.48) | HTR6HTR2BADRB2HTR2CHTR1A | |
| SCHEMBL20249449 | 0.76 | SOS1 (0.34) | HTR6HTR2BADRB2ADRA2AHTR2C | |
| SCHEMBL21414484 | 0.75 | ADRB1 (0.45) | HTR6HTR2BADRB2HTR2CHTR1A | |
| SCHEMBL20203439 | 0.75 | ADRB1 (0.45) | HTR6HTR2BADRB2HTR1AHTR7 | |
| SCHEMBL27841113 | 0.75 | MAPT (0.46) | HTR6HTR7ADRB1HTR3AHTR3E | |
| SCHEMBL29215308 | 0.74 | ADRB1 (0.44) | HTR6HTR2BADRB2ADRA2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | TEIJIN PHARMA LIMITED (JP) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | CDK4, CDK6, CDK16 | HTR6 476/4885HTR2B 3035/4885ADRB2 3638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.