SCHEMBL202553

SCHEMBL202553

COC(=O)/C=C/COc1ccc(F)c(C(N)=O)c1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.46
POLB P06746 2/20 0.46
FDPS P14324 1/20 0.35
TNKS2 Q9H2K2 1/20 0.33
BACE1 P56817 1/20 0.33
HTT P42858 2/20 0.32
LMNA P02545 1/20 0.32
PARP1 P09874 1/20 0.32
PARP15 Q460N3 1/20 0.32
PARP14 Q460N5 1/20 0.32
PARP10 Q53GL7 1/20 0.32
EPHX2 P34913 1/20 0.32
CTSD P07339 1/20 0.32
KDM4E B2RXH2 2/20 0.32
ALDH1A1 P00352 2/20 0.32
GAA P10253 2/20 0.32
JAK2 O60674 1/20 0.32
MAPT P10636 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
TTR P02766 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL202554 1.00 RAB9A (0.46) RAB9APOLBFDPSTNKS2BACE1
SCHEMBL201377 0.85 ALDH1A1 (0.33) RAB9APOLBTNKS2BACE1LMNA
SCHEMBL201378 0.85 ALDH1A1 (0.33) RAB9APOLBTNKS2BACE1LMNA
SCHEMBL200889 0.83 ATM (0.41) RAB9ALMNAALDH1A1MAPTSMN1; SMN2
SCHEMBL200888 0.83 ATM (0.41) RAB9ALMNAALDH1A1MAPTSMN1; SMN2
SCHEMBL10222524 0.78 HTR2C (0.45) PARP1KDM4EALDH1A1GAA
SCHEMBL201929 0.77 MEN1 (0.44) POLBTNKS2HTTLMNAKDM4E
SCHEMBL203638 0.77 KDM4E (0.42) LMNAEPHX2KDM4EALDH1A1MAPT
SCHEMBL203639 0.77 KDM4E (0.42) LMNAEPHX2KDM4EALDH1A1MAPT
SCHEMBL31609727 0.76 MAPK1 (0.46) RAB9ATNKS2HTTLMNAPARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250179008-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. (US) 2025-06-05 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 US disclosed
US-20130072520-A2 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2013-03-21 US disclosed
US-20130072520-A2 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2013-03-21 US disclosed
US-20120122918-A1 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2012-05-17 US disclosed
US-8088791-B2 Antibacterial agents Biots Scientific Management Pty Ltd (AU) 2012-01-03 US disclosed
US-8088791-B2 Antibacterial agents Biots Scientific Management Pty Ltd (AU) 2012-01-03 US disclosed
EP-1996180-B1 BENZAMIDE AND PYRIDYLAMIDE DERIVATIVES AS ANTIBACTERIAL AGENTS BIOTA EUROPE LTD (GB) 2011-08-03 EP disclosed
EP-1996180-B1 BENZAMIDE AND PYRIDYLAMIDE DERIVATIVES AS ANTIBACTERIAL AGENTS BIOTA EUROPE LTD (GB) 2011-08-03 EP disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
EP-1996180-A1 ANTIBACTERIAL AGENTS Prolysis Limited (GB) 2008-12-03 EP disclosed
WO-2007107758-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2007-09-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122918-A1 ANTIBACTERIAL AGENTS ALK, ROS1, ARG1 RAB9A 1213/4885POLB 445/4885FDPS 2063/4885
US-20130072520-A2 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 RAB9A 2799/4885POLB 364/4885FDPS 1719/4885
US-20150191420-A1 ANTIBACTERIAL AGENTS ALK, ARG1, ROS1 RAB9A 1340/4885POLB 435/4885FDPS 2147/4885
US-20250179008-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 RAB9A 2799/4885POLB 364/4885FDPS 1719/4885
US-20100173933-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 RAB9A 2799/4885POLB 364/4885FDPS 1719/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.