Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SHMT1 | P34896 | 4/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CTSD | P07339 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21560078 | 0.91 | SHMT2 (0.68) | SHMT2ALDH1A1KDM4EHPGDSHMT1 | |
| SCHEMBL20255903 | 0.88 | KDM4E (0.63) | SHMT2ALDH1A1KDM4EHPGDSHMT1 | |
| SCHEMBL21560050 | 0.88 | SHMT2 (0.52) | SHMT2ALDH1A1KDM4EHPGDSHMT1 | |
| SCHEMBL21560065 | 0.87 | TP53 (0.52) | SHMT2ALDH1A1KDM4EHPGDSHMT1 | |
| SCHEMBL20255892 | 0.87 | LMNA (0.58) | SHMT2ALDH1A1KDM4EHPGDSHMT1 | |
| SCHEMBL20255803 | 0.87 | SHMT2 (0.70) | SHMT2ALDH1A1KDM4EHPGDSHMT1 | |
| SCHEMBL21560002 | 0.87 | SHMT2 (0.53) | SHMT2ALDH1A1KDM4EHPGDSHMT1 | |
| SCHEMBL20255586 | 0.86 | KDM4E (0.59) | SHMT2ALDH1A1KDM4EHPGDSHMT1 | |
| SCHEMBL20255891 | 0.85 | SHMT1 (0.55) | SHMT2ALDH1A1KDM4EHPGDSHMT1 | |
| SCHEMBL21560291 | 0.83 | SHMT2 (0.66) | SHMT2ALDH1A1KDM4EHPGDSHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11091451-B2 | SHMT inhibitors and uses thereof | RAZE THERAPEUTICS, INC. (US) | 2021-08-17 | — | — | US | disclosed |
| US-20190345119-A1 | SHMT INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. | 2019-11-14 | — | — | US | disclosed |
| WO-2018106636-A1 | SHMT INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2018-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11091451-B2 | SHMT inhibitors and uses thereof | SHMT1, SHMT2, BHMT | SHMT2 2/4885ALDH1A1 189/4885KDM4E 344/4885 |
| US-20190345119-A1 | SHMT INHIBITORS AND USES THEREOF | SHMT1, SHMT2, BHMT | SHMT2 2/4885ALDH1A1 189/4885KDM4E 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.