Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 7/20 | 0.38 |
| ▸ | HTR6 | P50406 | 7/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17595789 | 0.87 | LMNA (0.43) | MAPTP2RX4MEN1KMT2APOLB | |
| SCHEMBL30406055 | 0.84 | ALDH1A1 (0.42) | MAPTRAB9AKDM4EMEN1TSHR | |
| SCHEMBL17596607 | 0.83 | GAA (0.37) | MAPTRAB9AKDM4EMEN1KMT2A | |
| SCHEMBL20259606 | 0.82 | HRH1 (0.32) | HRH1HTR6ADRA2AHTR2AHTR2C | |
| SCHEMBL17596379 | 0.82 | LMNA (0.33) | HRH1HTR6ADRA2AHTR2AHTR2C | |
| SCHEMBL25422550 | 0.80 | RAB9A (0.36) | MAPTRAB9AMEN1TSHRPOLB | |
| SCHEMBL19300387 | 0.79 | — | — | |
| SCHEMBL19300239 | 0.77 | PTGER4 (0.33) | RAB9AMEN1KMT2A | |
| SCHEMBL19687746 | 0.77 | CYP1A2 (0.34) | RAB9AMEN1KMT2A | |
| SCHEMBL19687618 | 0.77 | RAB9A (0.32) | RAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018106818-A1 | METHODS OF PROMOTING BETA CELL PROLIFERATION | KURA ONCOLOGY, INC. (US) | 2018-06-14 | — | — | WO | disclosed |